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Strokes

News, opinions and meeting coverage in critical care.

Lytics Help Imaging-Selected Patients Beyond 4.5-Hour Window

EXTEND trial shows less disability after use in 4.5-to-9-hour window

Andexanet Holds Strong as Antidote to Apixaban, Rivaroxaban

Reversal agent for factor Xa inhibitors soon to be subject to a randomized trial

Benefit of Endovascular Therapy Dwindles With Large-Core Strokes

But is thrombectomy still better than medical management alone for these cases?

Tighter BP Control No Better in Acute Stroke

But major limitations prevented firm conclusions in ENCHANTED trial

For Brain Bleeds, 'Gentle' but Thorough Surgery May Boost Outcomes

MISTIE III trial failed overall but showed functional benefit with extensive clot removal

BP Lowering en Route to Hospital Flops in Acute Stroke

RIGHT-2 trial shows no benefit, possible harm from nitroglycerin patch

Intensive Early Glucose Control No Help for Stroke Recovery

SHINE trial yields similar functional outcomes but higher hypoglycemia risk

Omega-3 and Vitamin D; Vein Grafts and CABG: It's PodMed Double T!

This week's topics include benefits of CABG, vein harvesting, new exercise guidelines, and omega-3 and vitamin D supplementation

AHA: Zetia May Cut CV Events in Japanese Seniors

Results from EWTOPIA75 trial not enough to change practice, experts says

FDA Approves Rivaroxaban for CV Prevention in CAD, PAD

Low dose to arrive in the U.S. next week

TCT: Studies Bolster Argument for Protected TAVR

Positive data ahead of CMS reimbursement decision

Vascepa Prevents Major Cardiovascular Events, Says Manufacturer

Big win for proprietary fish-oil product

Drop in Long-Term Stroke Complications with Newer LVAD

Data show even "mild" strokes are far from benign, though

Pre-Hospital Laryngeal Tube Ups Cardiac Arrest Survival

Trials cast doubt on endotracheal intubation as preferred treatment

Cath Lab Recap: Intracardiac Echo; Safe Late Lumen Loss Limit

Interventional cardiology news to note

NOAC's Brain Bleed Risk Outside Afib May Be Dose-Dependent

Higher risk seen only with higher rivaroxaban doses in meta-analysis

Don't Group Afib, Atrial Flutter Together in Evaluating Stroke Risk

Same CHA2DS2-VASc score, different outcomes

LAA Closure Device Thrombi 'Not Infrequent,' May Cause Strokes

Timing suggests causation in at least half of strokes with device-related thrombi

Retinal Abnormalities Predictor of Some Types of Stroke

Retinal imaging may offer noninvasive tool to determine pathogenesis of cerebral small vessel disease

Vibrating ICD/CRT-D; Pradaxa Reversal Agent; Prevention Bonanza

Recent developments of interest in cardiovascular medicine

AAN 2018: Rare Disease Breakthroughs and Novel Approaches

Noteworthy presentations at American Academy of Neurology meeting

Second BP Measurement Often Brings Better News

Repeat measurement in same office visit is on par with adding a drug

Novel Drug Reverses Anticoagulation in Emergencies

Andexanet stops 90% of action of factor Xa inhibitors

Perioperative Beta Blockers Trade Fewer MIs for More Deaths

Issue of safety highlighted again in POISE analysis

Cath Lab Recap: Pacemap Algorithm; Carotid Stent Over Perfusion; 3-D Valves

Interventional cardiology news to note

Afib and Ablation; Herbs and Drugs: This Week's PodMed Double T

This week's topics include herb/drug interactions, Afib and ablation in congestive heart failure, clot retrieval in stroke, and childhood kidney disease and adult end-stage renal disease

'A Time Clock to a Tissue Clock' for Acute Stroke Care

Stroke docs struggle with message after DAWN, DEFUSE 3, new guidelines

Novel Feeding Tube May Help Stroke Dysphagia

Electrical pharyngeal stimulation boosted readiness for decannulation

Novel Stent Retriever Is Quick to Restore Flow

More than half of recipients saw substantial reperfusion on first pass

Radiologists Did Most Stroke Thrombectomy In Early Days

But most had neurointerventional training in Medicare data up to mid-2015

Stent Retrievers and Aspiration On Par for Initial Thrombectomy Strategy

Stroke functional outcomes don't differ in head-to-head trial

Tenecteplase Superior to Alteplase for Stroke Lysis

But likelihood of gaining an official stroke indication appears remote

Guidelines Extend Thrombectomy Window to 24 Hours

Comprehensive update from AHA/ASA also expands lytic criteria

Cath Lab Recap: AAA Rupture Guidelines; Bioresorbable Stent

Interventional cardiology news to note

Could Squirrels Have the Answer to Stroke? (NetDoctor)

Turning on hibernation in humans may help preserve brain tissue

Study: Leave Tiny Brain Aneurysms Alone

Routine surveillance and coiling not linked to better survival

Study: Giving Oxygen No Help After Stroke

Trial showed no effect on death, disability in non-hypoxic acute stroke

Entresto Boosts Sex in HF; Venom Antidote to Xa Drugs; Guilty Plea for FH Vagueness

Recent developments of interest in cardiovascular medicine

ESC Roundup: IMPACT-AF; ORION-1; Swedish Registry

Three studies of note

ESC: Concomitant LAA Closure During Heart Surgery Scores a Win

But will making it routine safely prevent strokes?

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