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News, opinions and meeting coverage in dermatology.

ASCO: Herpes-Derived Tx for Melanoma?

CHICAGO -- Intralesional injection of an oncolytic therapy significantly increased the durable response rate in advanced melanoma compared with a control therapy, according to results of a randomized trial.

ASCO: Immune Therapy Durable in Melanoma

CHICAGO -- A therapy aimed at reviving the immune response to advanced melanoma generated durable responses in long-term follow-up of an early clinical trial, a researcher said here.

Tattoo Me: Tales of Regret and No Regrets

MIAMI BEACH -- Almost a third of people with tattoos regretted the decision to get body art, particularly men who obtained tattoos at a young age, a survey of more than 500 tattoo owners showed.

Lichen Planus in Ear Not Uncommon

MIAMI BEACH -- The autoimmune disease lichen planus may affect the ear more commonly than previously thought, researchers reported here.

UVB Exposure May Boost Low Vitamin D

MIAMI BEACH -- Narrowband UVB therapy may be a better treatment for vitamin D deficiency than supplementation, Swedish researchers reported here.

Novel Drug Works in Psoriasis

MIAMI BEACH -- An investigational phosphodiestirase-4 (PDE4) inhibitor may improve psoriasis, particularly in patients who haven't previously been treated, researchers reported here.

IL-4 Antibody Tames Atopic Dermatitis

MIAMI BEACH -- Atopic dermatitis disease activity declined significantly in patients treated with a monoclonal antibody directed against interleukin-4, according to pooled data from preliminary clinical trials.

Smokers Have Higher Squamous Cell Skin Ca Risk

Smokers have a more than 50% increase in risk for squamous cell carcinoma of the skin, and the risk remained elevated, even among those who'd kicked the habit, researchers found.

Prolia Linked to Serious Skin Side Effects

RALEIGH, N.C. -- More than 40 serious cutaneous adverse events linked to the osteoporosis formulation of denosumab (Prolia) were discovered in a review of FDA records, investigators reported here.

OTC Bug Bite Remedies of Little Help

Treating simple bug bites isn't usually necessary and there's little evidence to support doing so, a review warned.

Clinical Notes: Beware the Seat Heater

麻豆传媒 debuts a new regular feature, a roundup of clinical news you might otherwise have missed. This week we led with a report that heated car seats can leave passengers with "toasted skin syndrome."

Clindamycin Works Better for Skin Infections in Kids

For children with skin and soft tissue infections, clindamycin is the antibiotic of choice for empiric treatment, researchers found.

OTC Wart Remover Yanked Because of Burn Risk

An OTC wart remover product has been recalled by its manufacturer after the company learned that its active ingredient -- calcium oxide -- can cause severe chemical burns, the FDA announced.

Severe Acne Responds to Combo Therapy

Patients with severe acne had significantly greater improvement when topical adapalene/benzoyl peroxide (Epiduo) was added to oral doxycycline, according to results of a randomized clinical trial.

Scrubbing Away Germs Can Backfire on Backsides

Rashes from toilet seats are once again afflicting American children, and the rare condition is often misdiagnosed, which may delay proper treatment.

Rosacea May Be Caused by Immune Response, Not Bacteria

SAN DIEGO -- Acne rosacea appears to be caused by an overly zealous innate immune response and not by bacteria, investigators here said, suggesting new strategies for targeting inflammatory diseases.

Topical Retinol Bolsters Elderly Skin and Reduces Wrinkles

ANN ARBOR, Mich. -- Topical vitamin A (retinol) may improve fine wrinkles, collagen deficiency, and atrophy in the fragile skin of elderly patients.

Bug-Bite Diagnosis Starts from SCRATCH

BALTIMORE — Don't let the bedbug's bite go misdiagnosed, pediatric dermatologists here advise. A simple set of diagnostic principles may help to determine whether a child's rash comes from bedbug or flea bites, or something else.

FDA Warns of Two Eczema Agents' Possible Cancer Risks

ROCKVILLE, Md. - The FDA reported that two popular topical eczema drugs -- Elidel Cream (pimecrolimus) and Protopic Ointment (tacrolimus) -- have had black-box warnings about skin cancers and lymphoma added to their labels.

Epidural Steroid Injection Not Useful for Chronic Shingles Pain

UTRECHT, The Netherlands - An epidural injection of steroids with a local anesthetic did not provide the long-term pain relief doctors anticipated for patients suffering from post-herpetic neuralgia, researchers here said.

Botox Helps Patients Face Intractable Facial Pain

CURITIBA, Brazil - Everyone's favorite toxin appears to offer significant relief from intractable facial nerve pain.

California Judge Rules Tattoo Inks Must Carry Health Warnings

LOS ANGELES - A California Superior Court judge, citing health risks of lead and arsenic in tattoo inks, has ordered two major tattoo-ink manufacturers to carry warning labels.