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General Gastroenterology

News, opinions and meeting coverage in gastroenterology.

ACG over a photo of Pennsylvania Convention Center in Philadelphia, PA.

ACG Roundup: Young-Onset Barrett's Esophagus on the Rise

Selected highlights from the 2024 American College of Gastroenterology annual meeting

ACG over a photo of Pennsylvania Convention Center in Philadelphia, PA.

AI Colonoscopies: More Benign Lesion Removals, Potentially Higher Costs

At scale, the benefits of AI-assisted colonoscopy may not always outweigh the costs

ACG over a photo of Pennsylvania Convention Center in Philadelphia, PA.

Novel Drug Improved Symptoms in Eosinophilic Esophagitis

Monoclonal antibody cendakimab also reduced eosinophils compared with placebo

A selfie of Brittany Randall and her daughter Kamberlyn Bowler in Grand Junction Colorado in the summer of 2024.

Colorado Teen Fights Kidney Failure After Eating McDonald's Quarter Pounders

Deadly E. coli outbreak has been tentatively traced to contaminated onions

ACG over a photo of Pennsylvania Convention Center in Philadelphia, PA.

Low-Volume Bowel Prep Matches Standard for Inpatient Colonoscopy

Patients also found MoviPrep to be more tolerable and were more willing to repeat it

A photo of a McDonald鈥檚 Quarter Pounder hamburger and fries.

At Least 75 People Sickened as Deadly McDonald's E. Coli Outbreak Expands

Nearly two dozen people have been hospitalized

YouTube thumbnail with Siobhan Deshauer, MD, holding a red pepper and the words: SPICY SCIENCE.

Are Spicy Foods Dangerous to Your Organs?

Spicy foods may have health benefits, but they also carry some risk

IDWeek over a photo of the Los Angeles Convention Center in Los Angeles, CA.

Are Norovirus Vaccines on the Horizon?

Two candidates leverage unique technologies

A Look at Food-Related Illnesses at Restaurants Over the Years

While pretty rare for well-known restaurant chains, they do happen

FDA APPROVED FDA has approved zolbetuximab (Vyloy) over a computer rendering of a monoclonal antibody and cancer cells.

Novel Targeted Drug Approved for Stomach Cancers

Zolbetuximab indicated alongside fluoropyrimidine- and platinum-containing chemotherapy

A computer rendering of monoclonal antibodies and ulcerative colitis.

Novel Drug Maintained Clinical Improvements in IBD

Greater benefit seen with higher dose of tulisokibart at week 50

A photo of a female doctor writing on a clipboard.

Industry Clinic 鈥� Ad Insights

Why Are Liver Disease Patients Being Left Behind?

The YouTube thumbnail with a cartoon man in scrubs next to a pile of money and the words: Over $500k

Highest Paid Medical 麻豆传媒 in 2024

Each of these specialties average over $500k per year

The YouTube thumbnail with Siobhan Deshauer, MD, a photo of skin tags, and the words: HIGH SUGAR.

What Skin Says About Health

Knowing what to look for can mean the difference between life and death

A photo of male and female healthcare workers performing an endoscopy on a female patient.

Food Retention Risk Low for GLP-1 Users When Endoscopy Is Combined With Colonoscopy

Bowel preparation protocols appeared protective in small study

A photo of a stool collection container.

H. Pylori Testing Did Not Reduce Gastric Cancer Incidence, Mortality

Gastric cancer incidence was lower after adjusting for certain factors in post hoc analyses

FDA ODAC PD-(L)1 inhibitors over a computer rendering of esophageal cancer

No Benefit for PD-1 Inhibitors in Certain Gastroesophageal Cancers, FDA Panel Says

Despite problematic dataset, risk/benefit profile not favorable with PD-L1 expression below 1

A computer rendering of monoclonal antibodies.

Novel Monoclonal Antibody Shows Promise in Ulcerative Colitis

26% of patients receiving tulisokibart achieved clinical remission vs 1% with placebo

FDA ODAC PD-(L)1 inhibitors over a computer rendering of esophageal cancer

Immunotherapy May Not Benefit All Gastroesophageal Cancer Patients, FDA Staff Says

Data since approvals suggest benefits limited to subgroups with PD-L1 expression of at least 1%

FDA CRL tradipitant (Vanda) over a computer rendering of a stomach.

FDA Rejects NK1R Antagonist for Gastroparesis

Drugmaker none-too-pleased with agency's request for additional studies

FDA ADCOMM obeticholic acid (Ocaliva) over a computer rendering of a liver with the biliary tree highlighted.

Approved Liver Disease Drug Has No Clinical Benefit, FDA Panel Says

Agency advisors put their foot down on shaky science for Ocaliva in primary biliary cholangitis

FDA approved guselkumab (Tremfya) over a computer rendering of ulcerative colitis.

FDA Expands Approval of IL-23 Drug to Ulcerative Colitis

In trials, guselkumab more than doubled remission rates versus placebo

FDA ADCOMM obeticholic acid (Ocaliva) over a computer rendering of a liver with the biliary tree highlighted.

FDA Reviewers Skeptical of Ocaliva for Rare Bile Duct Disease

Agency advisory panel to examine complicated efficacy data and liver safety concerns

Thanks to Reddit, a New Diagnosis Is Bubbling Up Across the Nation

Botox can help "no-burp syndrome" symptoms

An xray image of the esophagus illuminated by a barium swallow.

Upper GI Damage Tied to Subsequent Parkinson's Disease

Mucosal damage seen on upper endoscopy associated with 76% higher Parkinson's risk

A close up photo of a nurse adjusting the flow rate of an intravenous infusion.

Study Backs Skipping 5-FU Bolus in Chemo Regimens for Gastrointestinal Cancers

No difference in overall survival with versus without bolus, less toxicity without

A photo of a radiologist monitoring a computer as a female nurse observes a patient during MRI.

The Higher the Disability Burden From Disease, the Higher the Suicide Risk

Having a medical condition was tied to increased risk of suicide in a dose-response-like manner

An electron micrograph of Clostridioides difficile bacteria

Another Injectable Toxoid Vaccine Flops for C. Diff

It's time to look at oral vaccines to prevent C. difficile infections, experts say

Olympic Chief Medical Officer on Athletes' GI Illness After Seine Events

IOC data show "about a 10% infection rate in those who swam in the Seine"

A computer rendering of stomach cancer.

Strong Support for Not Interrupting Imatinib Treatment in Advanced GIST

Worse progression-free, overall survival, shorter time to resistance after discontinuation

Medicare Unveils First 10 Negotiated Drug Prices

Prices slashed by as much as 79%

A photo of a nurse holding a bag of intravenous medication.

PBMs Are Stacking the Deck Against Patients and Independent Physician Practices

Infusion services and other therapies must be delivered without delay

A photo of Lauren Bell at Crescent Park in New Orleans

Younger Adults Are Going Public With Their Digestive Problems

Experts say it's mostly a good thing

A photo of a female nurse holding a tablet and speaking to her female patient.

Industry Clinic 鈥� Ad Insights

Our Understanding of IBD Has Come a Long Way—
So Have the Options to Treat It

Can App Data Link Sleep and Chronic Disease?; AI Model to Manage Diabetes

Also in TTHealthWatch: a monoclonal antibody for ulcerative colitis

IAC over a photo of Messe M眉nchen in Convention center in Munich, Germany

Two Tests Better Than One for Detecting Anal Cancer in People With HIV

Combination testing also tied to fewer referrals for further diagnostics

A photo of a man holding a fecal immunochemical test sample container

FIT Screening Linked to Lower Risk of Colorectal Cancer Mortality

Benefits with FIT screening were observed across racial and ethnic groups

The YouTube thumbnail with Siobhan Deshauer, MD, and the words: DRUNK WITHOUT DRINKING

This Medical Condition Got Him Arrested: Medical Mystery Solved

What caused this patient's alcohol intoxication?

A computer rendering of a transparent human body with the esophagus highlighted.

Benralizumab Led to Histologic Responses in Eosinophilic Esophagitis

But there was no significant difference in symptom relief compared with placebo

A computer rendering of a stomach ulcer.

PPI Prevents Upper GI Bleeds During Intubation, With No Effect on Mortality

But expert still suggests the approach may not be appropriate for the most severely ill

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