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Arthritis

News, opinions and meeting coverage in geriatrics.

FDA APPROVED adalimumab-adbm (Cyltezo) over a photo of a woman using an auto injector syringe.

First Interchangeable Humira Biosimilar Approved

Cyltezo nabs coveted "interchangeable" status for RA, inflammatory bowel disease, and more

A senior woman sitting on her couch looks at her hands clenched into fists.

In RA, Little Risk for Recurrent Cancer With Biologic Treatment

Results important because most trials excluded patients with previous cancer, researchers note

Four statin tablets outside of a blister pack

Statins Not Linked With Rheumatoid Arthritis, Large Study Finds

Risks attenuated after adjustment for lipid levels

A computer rendering of a lymph node cross section

Lymphoma in RA: Disease Activity Matters

Strongest risk factors were baseline disease activity scores and bone erosions

An image of of package of Xeljanz

FDA Slaps Restrictions on JAK Inhibitors Over Serious Safety Risks

Use for inflammatory conditions limited to those who fail on TNF blockers

A mature man laying on a couch winces from abdominal pain.

New-Onset IBD and IL-17 Inhibitors: What Is the Risk?

Underlying inflammatory disease severity should be taken into account

A doctor wearing blue rubber gloves holds the hand of a patient with psoriatic arthritis.

CV Risk in PsA: Do Drugs Matter?

Study weighs in on heart safety of TNF inhibitors versus other biologics

An x-ray image of erosive osteoarthritis of the hands.

Effective Treatments for Hand Osteoarthritis: The Search Goes On

Hydroxychloroquine not effective as disease-modifying drug for erosive hand OA, trial confirmed

A bottle and tablet of Rinvoq (upadacitinib) over an x-ray image of a spine with ankylosing spondylitis

Rinvoq Shows Promise in Spine Disease

1-year results in ankylosing spondylitis demonstrate efficacy for JAK inhibitor upadacitinib

Sagittal magnetic resonance images of psoriatic arthritis in the ankle region above a Stelara (ustekinumab) needle.

Target TNF or IL-12/23 in Psoriatic Arthritis?

Both TNF inhibitors and ustekinumab were effective in real-world use

A close up of a vial of methotrexate and a syringe in a man's hand

New ACR Rheumatoid Arthritis Guideline: Emphasis on Methotrexate

Many RA patients succeed with optimized use of the DMARD before adding another medication

A senior woman massages her painful arthritic hand

Pain Persists in RA, Even Without Inflammation

At 5 years, one-third of patients with rheumatoid arthritis still had "unacceptable" pain

A senior Asian woman sits on her couch experiencing knee pain.

Osteoarthritis: A Link With Parkinson's?

Inflammation may contribute to both joint and nerve degeneration

EULAR over a computer rendering of human body parts with the major joints glowing red

Rituximab a Hazard in RA Patients With COVID

Poor outcomes were fourfold higher among rituximab users than for those on TNF inhibitors

A man's hand with psoriatic arthritis over a box of Ilumya (tildrakizumab-asmn) for injection.

Plaque Psoriasis Drug Shows Promise for Psoriatic Arthritis

Monoclonal antibody targets the IL-23 p19 subunit

A Stelara auto injector needle over a grid of close up psoriasis images.

For Safety, One Biologic a Winner in Psoriasis, Psoriatic Arthritis

Lower hospitalization rates compared with other biologics or small molecule therapies

A Taltz (ixekizumab) auto injector pen over a photo of a mans back, his spine highlighted in red

Stopping IL-17 Drug for Axial Spondyloarthritis? Expect Spinal Flares

But low disease activity regained if treatment restarted

An illustration of a brain filled with lightbulbs, one is burning brightly, the others are dark.

The Death of One Little Girl Helped Millions

A case more than 35 years ago has spurred discoveries ever since

An artist rendition of fecal microbiota capsules

Results Disappoint for Fecal Transplant in Arthritis

But interest persists in targeting the gut-joint axis in psoriatic arthritis

NKF over a computer rendering of kidney disease

Pegloticase Safe for Dialysis Patients With Gout

Significant drop in monthly ESA dose seen after treatment, too

A Tremfya (guselkumab) syringe with the packaging box over a man's hand with enthesitis and psoriatic arthritis

For Enthesitis in Psoriatic Arthritis, Target IL-23

Targeted agent provides relief for many PsA patients

A close up of a man鈥檚 hand with psoriatic arthritis over a bottle of Rinvoq (upadacitinib) tablets

JAK Inhibitor Promising in Psoriatic Arthritis

Oral agent noninferior to adalimumab in joint symptoms

A computer rendering of monoclonal antibodies

FDA Panel Unhappy With Novel OA Pain Drug

Latest setback for troubled osteoarthritis biologic

The packaging of Taltz (ixekizumab) injection

Don't Stop Taltz in Psoriatic Arthritis

Significantly more patients relapsed, and more quickly, after withdrawal

A bottle of Rinvoq (upadacitinib) tablets over an x-ray image of a person鈥檚 arthritic hands

JAK Inhibitor a Hit With RA Patients

Superior to adalimumab on many patient-reported outcomes

A box of Xeljanz (tofacitinib) tablets over a background of thumbs down icons

JAK Inhibitor Misses Endpoint in Safety Study. Now What?

Major blow to popular class of oral rheumatology drugs

PET scans of a person showing severe vasculitis

PET Scans Reveal Vascular Inflammation

In giant cell arteritis, imaging confirmed clinical response

A Cosentyx injection pen over a hand with psoriasis

Spinal Benefits Seen With Cosentyx in PsA

First trial to evaluate response of axial symptoms in psoriatic arthritis to biologic treatment

A close up of a man鈥檚 foot with his big toe swollen from gout

Lifestyle Mods May Head Off Gout

Four addressable factors appear key

ACR over a computer rendering of a human skeleton with the joints of the fingers highlighted in red

TYK2 Inhibition Promising in Psoriatic Arthritis

Phase II study found significant benefits for two doses of novel agent

ACR meeting

COVID Complications Common with Rheumatic Disease

Adverse outcomes included acute kidney injury and congestive heart failure

ACR over a computer rendering of a human skeleton with the joints of the fingers highlighted in red

Rinvoq for RA: Benefits Persist Beyond 1 Year

Manufacturer's extension study shows no loss of clinical response

A female service member in camouflage fatigues tosses garbage into a burn pit

Military Burn Pits Linked With RA Seropositivity

Highest risks for anti-CCP antibodies seen for smokers and those with the HLA-DRB1 shared epitope genes

NSAIDs over a pregnant woman holding a white tablet and glass of water above FDA WARNING

FDA Warns Against NSAIDs in Pregnancy After 20 Weeks

Risk of kidney complications and low amniotic fluids may jeopardize fetus

VS between a package of Orencia (abatacept) and a bottle of Rinvoq (Upadacitinib) over a half yellow and half pink background

Upadacitinib, Abatacept Go Head to Head in RA

And the winner is... both, depending on whether efficacy or safety is the main criterion

A bearded middle-age man sitting in a chair holding his aching wrist

Depression and Biologic Use in Arthritis: Chicken or Egg?

Relationship appears to be bi-directional, researchers say

ASIPP over a close up photo of a senior man's pained face with a tear falling

Capsaicin Injection Improves Knee OA Pain

Investigational treatment targets capsaicin receptor to inactivate local pain fibers

Photo of a woman massaging her arthritic hand and wrist

Joint Effusion Protective in Hand OA

Unlike synovitis, which was linked with both pain and progression

A photo of Al Roker

Al Roker's Shoulder Replacement

"Today" co-host and weatherman battles osteoarthritis pain

A bottle of Olumiant (baricitinib) tablets

Baricitinib and Infections: What's the Risk?

Overall infections increased, but serious infections similar to placebo

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