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Arthritis

News, opinions and meeting coverage in geriatrics.

A bottle of Xeljanz tablets over yellow caution tape forming an X

Trial Data Confirm Heightened Risks With JAK Inhibitor

May help patients and clinicians better weigh benefit against adverse effects

The packaging and blister pack of Cymbalta

Muddled Picture for Antidepressant as Osteoarthritis Pain Reliever

Trial in primary care setting fails to confirm benefit seen in specialty clinics

A white rubber gloved hand injects platelet-rich plasma into a person鈥檚 knee

Another Trial, Another PRP Flop in Osteoarthritis

Fails to outperform saline in randomized trial

A photo of two feet, the right foot is swollen from gout.

Another Study Confirms Gout Benefit With SGLT2 Inhibitors

Gout risk reduction was significantly better than with DPP-4 inhibitors

A box of Cosentyx 150 mg solution for injection in two pre-filled pens

Biologic Disappoints for Arthritis Achilles' Inflammation

But phase III trial did find some patient-oriented benefits

ACR over a photo of the Moscone Center in San Francisco, CA.

Vitamin D and Disease Prevention: Worth Another Look?

Incidence of autoimmune disease decreased by 25-30% with dietary supplements

ACR over a photo of the Moscone Center in San Francisco, CA.

Early Biologics Better in Juvenile Idiopathic Arthritis

After 2 years, more patients on combo biologic/DMARD regimen had inactive disease

A computer rendering of ankle osteoarthritis

No Love for PRP in Ankle Osteoarthritis Trial

Dutch researchers throw cold water on popular therapy

A close up of a man scratching the psoriasis on the back of his hand

How Should Patients With Autoimmune Diseases Approach COVID Vaccination?

Mixed messaging and a lack of tailored research leaves providers and patients in the dark

FDA APPROVED adalimumab-adbm (Cyltezo) over a photo of a woman using an auto injector syringe.

First Interchangeable Humira Biosimilar Approved

Cyltezo nabs coveted "interchangeable" status for RA, inflammatory bowel disease, and more

A senior woman sitting on her couch looks at her hands clenched into fists.

In RA, Little Risk for Recurrent Cancer With Biologic Treatment

Results important because most trials excluded patients with previous cancer, researchers note

Four statin tablets outside of a blister pack

Statins Not Linked With Rheumatoid Arthritis, Large Study Finds

Risks attenuated after adjustment for lipid levels

A computer rendering of a lymph node cross section

Lymphoma in RA: Disease Activity Matters

Strongest risk factors were baseline disease activity scores and bone erosions

An image of of package of Xeljanz

FDA Slaps Restrictions on JAK Inhibitors Over Serious Safety Risks

Use for inflammatory conditions limited to those who fail on TNF blockers

A mature man laying on a couch winces from abdominal pain.

New-Onset IBD and IL-17 Inhibitors: What Is the Risk?

Underlying inflammatory disease severity should be taken into account

A doctor wearing blue rubber gloves holds the hand of a patient with psoriatic arthritis.

CV Risk in PsA: Do Drugs Matter?

Study weighs in on heart safety of TNF inhibitors versus other biologics

An x-ray image of erosive osteoarthritis of the hands.

Effective Treatments for Hand Osteoarthritis: The Search Goes On

Hydroxychloroquine not effective as disease-modifying drug for erosive hand OA, trial confirmed

A bottle and tablet of Rinvoq (upadacitinib) over an x-ray image of a spine with ankylosing spondylitis

Rinvoq Shows Promise in Spine Disease

1-year results in ankylosing spondylitis demonstrate efficacy for JAK inhibitor upadacitinib

Sagittal magnetic resonance images of psoriatic arthritis in the ankle region above a Stelara (ustekinumab) needle.

Target TNF or IL-12/23 in Psoriatic Arthritis?

Both TNF inhibitors and ustekinumab were effective in real-world use

A close up of a vial of methotrexate and a syringe in a man's hand

New ACR Rheumatoid Arthritis Guideline: Emphasis on Methotrexate

Many RA patients succeed with optimized use of the DMARD before adding another medication

A senior woman massages her painful arthritic hand

Pain Persists in RA, Even Without Inflammation

At 5 years, one-third of patients with rheumatoid arthritis still had "unacceptable" pain

A senior Asian woman sits on her couch experiencing knee pain.

Osteoarthritis: A Link With Parkinson's?

Inflammation may contribute to both joint and nerve degeneration

EULAR over a computer rendering of human body parts with the major joints glowing red

Rituximab a Hazard in RA Patients With COVID

Poor outcomes were fourfold higher among rituximab users than for those on TNF inhibitors

A man's hand with psoriatic arthritis over a box of Ilumya (tildrakizumab-asmn) for injection.

Plaque Psoriasis Drug Shows Promise for Psoriatic Arthritis

Monoclonal antibody targets the IL-23 p19 subunit

A Stelara auto injector needle over a grid of close up psoriasis images.

For Safety, One Biologic a Winner in Psoriasis, Psoriatic Arthritis

Lower hospitalization rates compared with other biologics or small molecule therapies

A Taltz (ixekizumab) auto injector pen over a photo of a mans back, his spine highlighted in red

Stopping IL-17 Drug for Axial Spondyloarthritis? Expect Spinal Flares

But low disease activity regained if treatment restarted

An illustration of a brain filled with lightbulbs, one is burning brightly, the others are dark.

The Death of One Little Girl Helped Millions

A case more than 35 years ago has spurred discoveries ever since

An artist rendition of fecal microbiota capsules

Results Disappoint for Fecal Transplant in Arthritis

But interest persists in targeting the gut-joint axis in psoriatic arthritis

NKF over a computer rendering of kidney disease

Pegloticase Safe for Dialysis Patients With Gout

Significant drop in monthly ESA dose seen after treatment, too

A Tremfya (guselkumab) syringe with the packaging box over a man's hand with enthesitis and psoriatic arthritis

For Enthesitis in Psoriatic Arthritis, Target IL-23

Targeted agent provides relief for many PsA patients

A close up of a man鈥檚 hand with psoriatic arthritis over a bottle of Rinvoq (upadacitinib) tablets

JAK Inhibitor Promising in Psoriatic Arthritis

Oral agent noninferior to adalimumab in joint symptoms

A computer rendering of monoclonal antibodies

FDA Panel Unhappy With Novel OA Pain Drug

Latest setback for troubled osteoarthritis biologic

The packaging of Taltz (ixekizumab) injection

Don't Stop Taltz in Psoriatic Arthritis

Significantly more patients relapsed, and more quickly, after withdrawal

A bottle of Rinvoq (upadacitinib) tablets over an x-ray image of a person鈥檚 arthritic hands

JAK Inhibitor a Hit With RA Patients

Superior to adalimumab on many patient-reported outcomes

A box of Xeljanz (tofacitinib) tablets over a background of thumbs down icons

JAK Inhibitor Misses Endpoint in Safety Study. Now What?

Major blow to popular class of oral rheumatology drugs

PET scans of a person showing severe vasculitis

PET Scans Reveal Vascular Inflammation

In giant cell arteritis, imaging confirmed clinical response

A Cosentyx injection pen over a hand with psoriasis

Spinal Benefits Seen With Cosentyx in PsA

First trial to evaluate response of axial symptoms in psoriatic arthritis to biologic treatment

A close up of a man鈥檚 foot with his big toe swollen from gout

Lifestyle Mods May Head Off Gout

Four addressable factors appear key

ACR over a computer rendering of a human skeleton with the joints of the fingers highlighted in red

TYK2 Inhibition Promising in Psoriatic Arthritis

Phase II study found significant benefits for two doses of novel agent

ACR meeting

COVID Complications Common with Rheumatic Disease

Adverse outcomes included acute kidney injury and congestive heart failure

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