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Dementia

News, opinions and meeting coverage in geriatrics.

A photo of a senior Asian man鈥檚 neck swollen from hypothyroidism

Hypothyroidism May Predict Dementia in Golden Years

Association wasn't seen before age 65, nor with hyperthyroidism

A computer rendering of a neuron releasing neurotransmitters.

ADHD Drugs May Treat Alzheimer's Cognitive Symptoms Effectively

Positive effect on global cognition, apathy in meta-analysis

A photo of a woman opening a jar of pickles.

Midlife Hand Grip Strength Tied to Subsequent Dementia

Is the relationship mainly vascular?

A photo of a normal brain next to a brain with advanced CTE.

Evidence of CTE Rare in Military Personnel

Limited number of cases preclude causal conclusions

SLEEP over a photo of the Charlotte Convention Center in North Carolina

Unstable Sleep Patterns Linked With Worsening Cognition

Longitudinal data put sleep variability in a negative light

A motion blurred photo of a senior man walking and a young boy running on a city sidewalk.

Walking Speed Helps Predict Future Dementia

Dual decline in gait speed and cognition tied to higher dementia risk

A graphic from the American Heart Association of Life鈥檚 Simple 7.

Even With High Genetic Risk for Alzheimer's, Lifestyle Factors Matter

Midlife scores on Life's Simple 7 tied to dementia incidence across a range of genetic profiles

A photo of a person鈥檚 foot with gout.

Is Gout Protective Against Dementia?

Provocative results from Korean study

A computer rendering of three trees shaped like human heads progressively losing their leaves

Dementia Risk Factors Vary By Age

Vascular factors at age 55 are different from those later in life

A computer rendering of a transparent brain with the choroid plexus highlighted.

Alzheimer's, Cognitive Impairment Linked With Choroid Plexus Volume

Blood-CSF barrier may play a role in Alzheimer's pathogenesis

A photo of a senior man eating a hot dog at a country fair.

Brain Aging Markers Tied to Inflammatory Foods

Smaller brain volume seen with diet-driven inflammation

A close up rubber gloved hands collecting cerebrospinal fluid with a vial from a spinal needle

Can Young Cerebrospinal Fluid Boost Cognition?

Brain fluid from young mice improved memory in older ones

FDA APPROVED Lumipulse G 尾-Amyloid Ratio (1-42/1-40) test over a computer rendering of amyloid plaques around neurons.

Early Alzheimer's Test Gets FDA Nod

First in vitro diagnostic to detect amyloid in early disease setting

A close up of a woman鈥檚 hand gnarled by arthritis resting on the head of a cane.

Is Alzheimer's Risk Lower With TNF Inhibitors?

For arthritis patients with cardiovascular disease, the answer may be yes

AAN over a photo of the Washington State Convention Center, Seattle, WA.

Memory Enhancer Succeeds in Phase II Alzheimer's Trial

Novel NMDA-targeted drug would expand options for symptomatic treatment

A photo of the vial and packaging of Aduhelm.

Aducanumab Data Finally Published, but Alzheimer's Experts Spot Problems

Questions raised about secondary endpoints

A computer rendering of the heart with the left atrium highlighted.

Left Atrial Disease Linked to Incident Dementia

Echocardiographic findings suggest more therapeutic targets for dementia

A photo of pink lithium capsules.

Lithium Linked to Dementia Prevention

Study found lower risk of developing Alzheimer's, vascular dementia

A senior woman sitting in bed massages her toes.

Peripheral Nerve Problems Tied to Later Dementia

Findings may indicate shared susceptibility to neurodegeneration

Medical staff members from Jiangsu Province work at an ICU ward of the First Hospital of Wuhan City in Wuhan, central China

Cognitive Effects Persist in Older COVID Patients

Long-term cognitive decline common after SARS-CoV-2 hospitalization

A portrait of a mature bearded man with a tabby cat draped over his shoulder.

Owning a Pet May Protect Cognitive Health

Strongest benefit seen for long-term pet owners

A senior man sits in a chair next to his bed and looks out the window.

Loneliness May Triple Dementia Risk

Even without dementia, lonely feelings linked with brain changes

A cross section slice of a brain with Alzheimer鈥檚 disease

COVID Brain Changes Show Parallels With Alzheimer's Disease

Findings may point to potential mechanism for brain fog in people with long COVID

A blue rubber gloved hand holds a test tube of blood in front of a brain MRI

Blood Biomarkers May Distinguish Dementia Disorders

Plasma levels show diagnostic, prognostic performance in varying dementia types

A blood pressure cuff, a stethoscope and a spilled prescription bottle of green pills.

Mixing and Matching BP Meds? Consider the Implications for Dementia

SPRINT analysis favors certain classes of antihypertensives

An illustration depicting Alzheimer鈥檚 disease with amyloid plaques forming between neurons

Alzheimer's Drugs Race to FDA

After aducanumab, drug companies pivot to use the accelerated approval pathway

A photo of Viagra pills blister pack and packaging.

Can Viagra Prevent Alzheimer's?

Sildenafil shows potential for drug repurposing

An illustration of a heartbeat over a silhouette of a senior woman.

Dementia Tied to Resting Heart Rate

Findings persist even after accounting for cardiovascular disease

AHA over a computer rendering of the heart.

Aspirin Flops Again for Dementia Prevention

ASCEND trial sides with ASPREE, but can't rule out some potential benefit

AHA over a computer rendering of the heart.

Two Anticoagulants -- When Used Correctly -- Similarly Protective Against Dementia

GIRAF trial tested warfarin versus dabigatran in older Afib patients

EASD over an illustration of a person's hand and blood glucose monitor and other icons associated with diabetes.

Healthy Lifestyle Keeps Dementia at Bay in Patients With Diabetes

Maintaining control of risk factors neutralized excess dementia risk

A close up of a man's white rubber gloved hand picking up a bullet shell from the floor with tweezers.

Preventing Gun Violence in Patients With Dementia

Gun safety advocate Emmy Betz, MD, MPH, offers advice

A computer rendering of beta-amyloid protein forming plaques and collecting between neurons.

Amyloid Tipping Point Helps Predict Alzheimer's Dementia Onset

Algorithm requires only one PET scan and age

Feared ARNI Effect on Cognition Hasn't Come to Fruition

Neurocognitive protection by sacubitril/valsartan suggested instead by observational study

A computer rendering of a heart cross section with implanted left ventricular assist device

Some Reassurance on Cognition in People With Older LVADs

Will newer devices look even better for neurological outcomes?

A technician prepares blood samples for mass spectrometry

Blood Test Discerns Alzheimer's From Other Dementia With High Accuracy

Plasma p-tau moves another step closer to clinical use

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Driving Patterns Pinpoint Early Alzheimer's Disease

Subtle shifts in on-road behavior suggest GPS-based biomarkers may have merit

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

COVID-19: Persistent Cognitive Effects, Uptick in Alzheimer's Biomarkers

Findings link cognitive impairment and long-lasting anosmia

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Aducanumab: What to Know If You Prescribe

Recommendations may change when trial data are published

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Better Air, Better Brains

Reducing air pollution tied to lower dementia risk, slower cognitive decline

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