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News, opinions and meeting coverage in oncology/hematology.

A computer rendering of a chronic lymphocytic leukemia cell.

BTK Inhibitor Active in Half of Patients With Richter Transformation

Responses to pirtobrutinib observed in patients with previously treated disease

A computer rendering of sickle cells in the blood.

Lung Function Stable in Sickle Cell Patients After Non-Myeloablative Transplant

Results from some pulmonary function tests even showed improvement 3 years post-transplant

A photo of a lab technician moving a bag of cultivated hematopoietic stem cells

Mixed Results With Cyclophosphamide in Mismatched Unrelated Stem Cell Transplants

Better survival in one registry study, detriment with class I HLA mismatch in another

FDA EUA Pemivibart (Pemgarda) over a photo of the packaging and vial of Pemgarda.

FDA Could Soon Limit Use of Only Drug for COVID Prevention

Pemivibart may have reduced activity against growing variant KP.3.1.1, agency warns

A computer rendering of sickle cells blocking blood flow.

Too Many Kids With Sickle Cell Disease Aren't Getting Appropriate Preventive Care

Findings from my recent study shook me to my core

Onco Break over a computer rendering of a cancer cell.

More Support for Early Detection; Cancer in Men Rising; Diet Drives Colon Cancer

News, features, and commentary about cancer-related issues

FDA APPROVED axatilimab-csfr (Niktimvo) over a computer rendering of antibodies.

Novel Agent for Chronic GVHD Wins FDA Approval

Axatilimab achieved a 75% response rate in patients with previously treated chronic GVHD

Onco Break over a computer rendering of a cancer cell.

No Gestational Diabetes-Cancer Link; Cholesterol and Cancer; Oncologist Saves Umpire

News, features, and commentary about cancer-related issues

FDA APPROVED denileukin diftitox (Lymphir) over a photo of cutaneous T-cell lymphoma.

IL-2 Receptor-Targeted Therapy Approved for Relapsed/Refractory CTCL

New iteration of denileukin diftitox led to objective responses in 36% of pretreated patients

Onco Break over a computer rendering of a cancer cell.

Approval in Endometrial Cancer Expanded; Masks at Cancer Centers; NPR Reporter Dies

News, features, and commentary about cancer-related issues

FDA APPROVED daratumumab-hyaluronidase (Darzalex Faspro), bortezomib (Velcade), lenalidomide (Revlimid), and dexamethasone

FDA OKs Subcutaneous Daratumumab Plus VRd for Myeloma

Indicated for newly diagnosed patients who are eligible for stem cell transplant

Onco Break over a computer rendering of a cancer cell.

Ancient DNA May Fuel Cancer; ASCO Appeals to Oncologists; Pesticide Cancer Risk

News, features, and commentary about cancer-related issues

A photo of an Olympic venue in Paris decorated for the 2024 Summer Olympics.

These Athletes Weren't Doping. Their Genes Made It Look Like They Did.

Advanced sequencing revealed genetic reasons for high hemoglobin, hematocrit levels

A photo of a smiling woman holding a positive pregnancy test.

'Realistic Chance for Pregnancy' After Stem Cell Transplant, German Study Suggests

77% of pregnancies resulted in live births

Onco Break over a computer rendering of a cancer cell.

Top Cancer Centers; Phase III Win in Prostate Cancer; Screening Recs for Anal Cancer

News, features, and commentary about cancer-related issues

A computer rendering of blood escaping from a broken vessel.

Efanesoctocog Alfa Prevented Bleeding in Kids With Severe Hemophilia A

No factor VIII inhibitors developed among the 74 boys included in the study

Onco Break over a computer rendering of a cancer cell.

A First in Total Larynx Transplant; 'Sniffing' Out Lung Cancer; Gen X Cancer Toll

News, features, and commentary about cancer-related issues

A computer rendering of multiple myeloma cells.

Refractory Multiple Myeloma Responsive to Immunotherapy Plus Low-Dose Radiotherapy

A third of patients who had received multiple prior lines of therapy responded, small study shows

Belantamab Mafodotin: The Comeback Drug in Multiple Myeloma

Joseph Mikhael, MD, leads a discussion on the DREAMM-7 and DREAMM-8 trials

Onco Break over a computer rendering of a cancer cell.

Unexplained CAR-T Death; Americans Spurn Sunscreen; Improving Diversity in Trials

News, features, and commentary about cancer-related issues

A photo of a female teen wearing a head scarf being comforted by her mother.

Young Cervical Cancer, Leukemia Survivors at Greater Risk of Obstetric Complications

Population-based study suggests reassurance for most, high-risk strategies for some

FDA APPROVED crovalimab (Piasky) over a computer rendering of blood flowing inside a vessel.

Subcutaneous C5 Inhibitor Approved for PNH

Longer-acting crovalimab designed for more sustained effect and less treatment burden

Onco Break over a computer rendering of a cancer cell.

EU Adds CAR-T Warning; New Blincyto Indication; Good News in Pancreatic Cancer

News, features, and commentary about cancer-related issues

EHA over a photo of IFEMA Madrid in Spain.

Glofitamab Regimen Improves Survival in DLBCL

Granted accelerated approval last year, bispecific antibody passes its confirmatory test

Using MRD Status to Deescalate Multiple Myeloma Therapy

Joseph Mikhael, MD, leads a discussion on the findings of the MRD2STOP study

A computer rendering of diffuse large B-cell lymphoma cells.

Multidrug Regimen Could Change Treatment Landscape for Relapsed/Refractory DLBCL

High-rate of durable responses with ViPOR sparks talk of supplanting CAR-T in second line

A computer rendering of monoclonal antibodies.

Novel Anti-CD38 Drug Shows Promise for Immune Thrombocytopenia

"Rapid and sustained" efficacy in 95% of pretreated patients in small trial

EHA over a photo of IFEMA Madrid in Spain.

Three-Drug Regimens Make Case for a Role in Untreated and Relapsed/Refractory CLL

Undetectable MRD rates of 90% or higher, PFS of 7 years or more

EHA over a photo of IFEMA Madrid in Spain.

New Standard of Care in High-Risk Acute Promyelocytic Leukemia?

All-trans retinoic acid plus arsenic trioxide and idarubicin improved EFS over standard

EHA over a photo of IFEMA Madrid in Spain.

Atezolizumab Consolidation Impresses in High-Risk DLBCL

Will 2-year DFS of 88%, OS of 96% renew interest in checkpoint inhibitor consolidation?

Adding Isatuximab to Standard Backbone Prolongs PFS in Myeloma

Joseph Mikhael, MD, leads a roundtable discussion on two positive phase III trials from ASCO

Onco Break over a computer rendering of a cancer cell.

Upping Immunotherapy Activity; A Win for Lung Screening; Looming Drug Price Break?

News, features, and commentary about cancer-related issues

A computer rendering of CAR T cell therapy in Diffuse large B-cell lymphoma

New Clues to Origin of T-Cell Lymphoma After CAR-T Therapy

Co-mutations, viral link, potential common susceptibility emerge from two studies

A photo of Alunbrig (brigatinib) tablets.

Brigatinib Makes Its Case for ALK-Positive ALCL in Small Study

Second-gen ALK inhibitor induces high response rate, associated with impressive survival

FDA APPROVED imetelstat (Rytelo) over a photo of a bag of blood in blue rubber gloved hands.

Telomerase Inhibitor Approved for MDS-Related Anemia

Imetelstat indicated for lower-risk myelodysplastic syndromes with transfusion-dependent anemia

A photo of a female radiologist readying her male patient for radiotherapy.

Near-Perfect Control of Slow-Growing Lymphoma With Low-Dose Radiotherapy

All but four of 24 patients had complete responses to 4 Gy, local control rate of 96% at 3 years

Onco Break over a computer rendering of a cancer cell.

'Unusual' Cancers After Pandemic; A Win in TNBC; Shortage Pauses Clinical Trial

News, features, and commentary about cancer-related issues

Morning Break over illustration of a syringe, Covid virus, and DNA helix over a photo of green vegetation.

Star Singer's Illness; AI Imitating the Dead; Internet-Addicted Brains

Health news and commentary gathered by 麻豆传媒 staff

ASCO over a photo of McCormick Place in Chicago, IL

Triplet Notches Survival Win in Heavily Pretreated DLBCL

Benefit with BV plus lenalidomide-rituximab seen in those who relapsed after CAR-T or transplant

ASCO over a photo of McCormick Place in Chicago, IL

Blenrep-Based Regimen Yields PFS Benefit in Relapsed/Refractory Myeloma

Second belantamab mafodotin-containing triplet to show potency in this setting

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