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Hematology

News, opinions and meeting coverage in oncology/hematology.

EHA over a photo of IFEMA Madrid in Spain.

Atezolizumab Consolidation Impresses in High-Risk DLBCL

Will 2-year DFS of 88%, OS of 96% renew interest in checkpoint inhibitor consolidation?

Adding Isatuximab to Standard Backbone Prolongs PFS in Myeloma

Joseph Mikhael, MD, leads a roundtable discussion on two positive phase III trials from ASCO

Onco Break over a computer rendering of a cancer cell.

Upping Immunotherapy Activity; A Win for Lung Screening; Looming Drug Price Break?

News, features, and commentary about cancer-related issues

A computer rendering of CAR T cell therapy in Diffuse large B-cell lymphoma

New Clues to Origin of T-Cell Lymphoma After CAR-T Therapy

Co-mutations, viral link, potential common susceptibility emerge from two studies

A photo of Alunbrig (brigatinib) tablets.

Brigatinib Makes Its Case for ALK-Positive ALCL in Small Study

Second-gen ALK inhibitor induces high response rate, associated with impressive survival

FDA APPROVED imetelstat (Rytelo) over a photo of a bag of blood in blue rubber gloved hands.

Telomerase Inhibitor Approved for MDS-Related Anemia

Imetelstat indicated for lower-risk myelodysplastic syndromes with transfusion-dependent anemia

A photo of a female radiologist readying her male patient for radiotherapy.

Near-Perfect Control of Slow-Growing Lymphoma With Low-Dose Radiotherapy

All but four of 24 patients had complete responses to 4 Gy, local control rate of 96% at 3 years

Onco Break over a computer rendering of a cancer cell.

'Unusual' Cancers After Pandemic; A Win in TNBC; Shortage Pauses Clinical Trial

News, features, and commentary about cancer-related issues

Morning Break over illustration of a syringe, Covid virus, and DNA helix over a photo of green vegetation.

Star Singer's Illness; AI Imitating the Dead; Internet-Addicted Brains

Health news and commentary gathered by 麻豆传媒 staff

ASCO over a photo of McCormick Place in Chicago, IL

Triplet Notches Survival Win in Heavily Pretreated DLBCL

Benefit with BV plus lenalidomide-rituximab seen in those who relapsed after CAR-T or transplant

ASCO over a photo of McCormick Place in Chicago, IL

Blenrep-Based Regimen Yields PFS Benefit in Relapsed/Refractory Myeloma

Second belantamab mafodotin-containing triplet to show potency in this setting

ASCO over a photo of McCormick Place in Chicago, IL

Kinder, Gentler Regimen for Classical Hodgkin Prevails in Randomized Trial

Better efficacy with brentuximab vedotin versus standard chemo, substantially less toxicity

Onco Break over a computer rendering of a cancer cell.

Fewer Suicides in Cancer Patients; Circadian Rhythm Boost; HIV Vaccine for Cancer?

News, features, and commentary about cancer-related issues

ASCO over a photo of McCormick Place, in Chicago, IL

STAMP Inhibitor Tops Imatinib, Second-Gen TKIs for Newly Diagnosed CML

The benefit-risk profile could change the treatment paradigm in CML, expert says

A photo of a male artist tattooing his male client in a parlor in Stockholm, Sweden.

Tattoos May Be a Risk Factor for Lymphoma

Swedish study suggests a 21% higher risk for lymphoma in those with tattoos

The YouTube thumbnail for this video with a cartoon nurse and the words: MOST BURNT OUT SPECIALTY

Five Doctor 麻豆传媒 With the Most Burnout in 2024

Emergency medicine and ob/gyn top the list

A computer rendering of antibodies in the blood.

Doubt Cast on MGUS-Autoimmune Disease Link

Population-based study fails to confirm earlier findings

A photo of infected blood victim Brendan West.

What to Know About the U.K.'s Tainted Blood Scandal

Tens of thousands contracted HIV or hepatitis from transfusions during the 1970s and 1980s

Mortality in U.S. Youth; Gene Therapy for Sickle Cell Disease

Also in TTHealthWatch: updated breast cancer screening guidelines

Onco Break over a computer rendering of a cancer cell.

Cancer Vaccines' Emergence; More Focus on Side Effects; A Nudge for Exercise

News, features, and commentary about cancer-related issues

A computer rendering of acute myeloid leukemia cells in the blood.

Venetoclax Combo Safe, Effective in AML Patients Age 80 and Up, Real-World Data Show

Study finds survival is comparable to that seen in younger patients in VIALE-A trial

A photo of a box of Adzynma

Impact of Recombinant Replacement Therapy Detailed in Genetic Clotting Disorder

Trial that led to FDA approval shows a big difference in replacement levels versus usual care

A photo of a lab technician using a pipette to transfer a sample to a multi well plate in a laboratory.

Genetics and Genetic Testing to Inform Myelofibrosis Clinical Management

Genetics already informs prognosis, may help guide therapy development beyond JAK2 inhibition

A computer rendering of Myelofibrosis cells in the blood

Myelofibrosis: A Rare Malignancy Attracting More and More Attention

Increased interest follows mutation discoveries, development of targeted therapies

Morning Break over illustration of a syringe, Covid virus, and DNA helix over a photo of green vegetation.

New E. Coli Outbreak; How ECMO Redefines Death; A Step Closer to Universal Blood

Health news and commentary gathered by 麻豆传媒 staff

FDA APPROVED mavorixafor (Xolremdi) over a photo of warts on a woman鈥檚 hand.

FDA Approves First Drug for WHIM Syndrome

CXCR4 antagonist mavorixafor effectively boosts neutrophils and lymphocytes to reduce infections

Onco Break over a computer rendering of a cancer cell.

Clue to Aspirin, Colon Cancer Link; New Lutathera Approval; AI & Electronic Records

News, features, and commentary about cancer-related issues

Illustration of red blood cells.

FDA OKs Second Gene Therapy for Hemophilia B

One dose of fidanacogene elaparvovec proved noninferior to standard prophylactic factor IX

An image of isatuximab tablets.

Quadruplet Shows 'Excellent Activity' in Myeloma Patients Who Defer HSCT

ORR reaches 90% with isatuximab plus KRd in newly diagnosed disease

Illustration of blood cells with circulating tumor cells.

High Deep-Remission Rate With Triple Regimen for Relapsed/Refractory CLL

Undetectable disease rate over 90%, ctDNA also promising for earlier detection of recurrence

Illustration of an engineered T-cell attacking a leukemia cell.

CAR-T Plus Stem-Cell Transplant Promising for CD7+ Blood Cancers

"All-in-one" approach appears safe, effective, in patients with relapsed/refractory disease

A photo of a pregnant woman napping while receiving chemotherapy.

Immunotherapy During Pregnancy Just as Safe as Other Cancer Drugs

However, use should be avoided "if possible" due to risk of rare immune-related adverse events

FDA APPROVED ciltacabtagene autoleucel (Carvykti), idecabtagene vicleucel (Abecma) over 3D multiple myeloma cells.

FDA Approves Earlier Use of CAR-T Products for Myeloma

Carvykti and Abecma move to second- and third-line, respectively

ACC over a photo of Georgia World Congress Center in Atlanta, GA

High Response Rate in R/R Multiple Myeloma With Bispecific Antibody

ORR of 71% that deepened over time and favorable safety profile with linvoseltamab

FDA APPROVED danicopan (Voydeya) over a computer rendering of red blood cells.

Factor D Inhibitor Wins Approval for PNH With Extravascular Hemolysis

Danicopan significantly improved hemoglobin at 12 weeks when added to a C5 inhibitor

FDA APPROVED ceftobiprole medocaril sodium (Zevtera) over a computer rendering of Staphylococcus aureus bacteria

FDA OKs Injectable Antibiotic for Three Different Uses

Ceftobiprole was at least comparable to currently used medications in studies

Onco Break over a computer rendering of a cancer cell.

Chemo and Heart Disease; Flawed Lung Cancer Screening; New Vax Recommendations

News, features, and commentary about cancer-related issues

A computer rendering of white blood cells with T-cell lymphoma.

PD-1 Inhibitor Plus Chemotherapy Shows Promising Activity in Rare Lymphoma

The combination induced responses in all 34 patients with advanced extranodal NK/T-cell lymphoma

A photo of a woman breastfeeding her baby at home.

Breastfeeding Tied to Reduced Childhood Leukemia Risk

Lower pediatric ALL risk in Danish study when mothers exclusively breastfed for 3 months or more

FDA EUA pemivibart (Pemgarda) over a computer rendering of antibodies attacking COVID viruses.

New Monoclonal Authorized to Prevent COVID in Immunocompromised People

No such option has been available since FDA revoked the authorization of Evusheld last year

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