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Oncology/Hematology

News, opinions and meeting coverage in oncology/hematology.

Belantamab Mafodotin: The Comeback Drug in Multiple Myeloma

Joseph Mikhael, MD, leads a discussion on the DREAMM-7 and DREAMM-8 trials

A computer rendering of an oligonucleotide aptamer attacking a cancer cell.

Can Oligonucleotide Infusions Really Fix Lyme, Cancer, and Other Diseases?

U.S. clinics market oligonucleotide therapy for a wide range of conditions, without much evidence

A computer rendering of a transparent body with cancer of the larynx highlighted.

More Data Link Obesity to Better Survival for Cancer Patients on Immunotherapy

Higher BMI also associated with improvements in functional outcomes in this setting

Experts Discuss Groundbreaking Advances in EGFR-Mutant Lung Cancer

Discussion highlights insights from the LAURA trial and others on emerging treatments

A close up photo of a man smoking an ecigarette.

Vapers May Be Less Likely to Undergo Lung Cancer Screening

"Former smokers who use e-cigarettes remain at increased risk of lung cancer," researchers say

A photo of a PET/CT scanner.

PSMA PET Beats MRI in Prostate Cancer Staging Study

Findings support PSMA PET in the preoperative workflow of intermediate- and high-risk tumors

Pivotal Studies in Double-Expressor DLBCL Yield Divergent Results

R-CHOP plus venetoclax falls short, while R-CHOP with HDAC inhibitor shows promise

A photo of a female physician examining a mammogram.

Screening Mammography Performance Improved, Workload Decreased With AI Assistance

How European data play out in U.S. mammography environment remains to be seen

A photo of a man standing on a balance board.

Neuromuscular Training Decreased Incidence of Chemo-Induced Peripheral Neuropathy

Incidence significantly reduced with two types of exercises versus usual care

Onco Break over a computer rendering of a cancer cell.

Unexplained CAR-T Death; Americans Spurn Sunscreen; Improving Diversity in Trials

News, features, and commentary about cancer-related issues

A photo of patients receiving chemotherapy in an infusion clinic.

Study Supports More Inclusive Clinical Trials With Broader Eligibility Criteria

No difference in adverse events, clinical benefit, OS for patients with or without waivers

A photo of a female teen wearing a head scarf being comforted by her mother.

Young Cervical Cancer, Leukemia Survivors at Greater Risk of Obstetric Complications

Population-based study suggests reassurance for most, high-risk strategies for some

CAR T-Cell Therapy in Functional High-Risk Multiple Myeloma

Joseph Mikhael, MD, leads a discussion on the subgroup analysis of CARTITUDE-4

A photo of a blue rubber gloved hand holding a test tube of blood labeled: PSA Test.

What's a Normal PSA Value for Transgender Women on Estrogen Therapy?

Study suggests threshold is too high to identify risk of prostate cancer in this population

A photo of a female technician preparing a chemotherapy treatment in a glove box.

Oncology Drug Shortages Persist, but Continue to Evolve

Supply-chain issues, unrealistically low prices for generics, hoarding, other factors to blame

A close up photo of the hands of an adolescent receiving infusion therapy.

Temsirolimus Plus Chemotherapy Fails in Rare Childhood Cancer

Adding the mTOR inhibitor didn't improve EFS in intermediate-risk rhabdomyosarcoma

A computer rendering of a liver under a red umbrella.

Real-World Analysis Identifies Meds Tied to Higher Risk of Liver Injury

Case reports may not be as reliable, researchers say

Combo of Approved Agents Active in High-Risk Large B-Cell Lymphoma

Our panel of experts discusses mosunetuzumab/polatuzumab vedotin for relapsed/refractory patients

A close up photo of an acupuncture needle between a woman鈥檚 fingers.

Acupuncture Reduced Hot Flashes Related to Endocrine Therapy for Breast Cancer

64% of women reported at least a 50% reduction in hot flash frequency and severity

FDA APPROVED crovalimab (Piasky) over a computer rendering of blood flowing inside a vessel.

Subcutaneous C5 Inhibitor Approved for PNH

Longer-acting crovalimab designed for more sustained effect and less treatment burden

Treating Advanced Breast Cancer After Progression on CDK4/6 Inhibitors

Results from postMONARCH offer one path

A photo of the HealthCare.gov website.

Court: Some Employers Can Exclude PrEP, Cancer Screenings From Insurance Coverage

Not all preventive care recommended by the USPSTF is threatened by the narrow ruling, however

FDA APPROVED adagrasib (Krazati) over a computer rendering of colorectal cancer.

Adagrasib Wins Accelerated Approval for KRAS-Mutant Colorectal Cancer

KRAS inhibitor plus cetuximab achieved 34% response rate, 85% disease control in early trial

ASTRO Guideline Addresses Specifics of HPV-Associated Oropharyngeal Cancer

Clinical landscape has shifted away from traditional risks for H&N cancer to HPV predominance

A computer rendering of a meningioma.

ALK Inhibitor Shows Promise in Rare, Progressive Tumor Types

Phase II study found brigatinib exceeded historical control by shrinking 10% of targeted tumors

Onco Break over a computer rendering of a cancer cell.

EU Adds CAR-T Warning; New Blincyto Indication; Good News in Pancreatic Cancer

News, features, and commentary about cancer-related issues

A computer rendering of a transparent body with a tumor in the lungs highlighted.

Anti-PD-L1 Plus Targeted Agent No Better Than Chemo for Resistant NSCLC

No significant difference between atezolizumab-cabozantinib, docetaxel for OS, PFS, response

EHA over a photo of IFEMA Madrid in Spain.

Glofitamab Regimen Improves Survival in DLBCL

Granted accelerated approval last year, bispecific antibody passes its confirmatory test

Using MRD Status to Deescalate Multiple Myeloma Therapy

Joseph Mikhael, MD, leads a discussion on the findings of the MRD2STOP study

A computer rendering of diffuse large B-cell lymphoma cells.

Multidrug Regimen Could Change Treatment Landscape for Relapsed/Refractory DLBCL

High-rate of durable responses with ViPOR sparks talk of supplanting CAR-T in second line

A computer rendering of monoclonal antibodies.

Novel Anti-CD38 Drug Shows Promise for Immune Thrombocytopenia

"Rapid and sustained" efficacy in 95% of pretreated patients in small trial

EHA over a photo of IFEMA Madrid in Spain.

Three-Drug Regimens Make Case for a Role in Untreated and Relapsed/Refractory CLL

Undetectable MRD rates of 90% or higher, PFS of 7 years or more

FDA APPROVED durvalumab (Imfinzi), pembrolizumab (Keytruda) over an illustration of endometrial cancer.

Two New Immunotherapy-Chemo Options Approved for Endometrial Cancer

New indications for pembrolizumab and durvalumab in advanced disease

EHA over a photo of IFEMA Madrid in Spain.

New Standard of Care in High-Risk Acute Promyelocytic Leukemia?

All-trans retinoic acid plus arsenic trioxide and idarubicin improved EFS over standard

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I Tried to Protect My Mother From Dying in Pain. The Law Robbed Her of That Dignity.

It's time to clear the roadblocks to Medical Aid in Dying in the U.S.

Train Eyes So Myopia Doesn't Get Worse? Nurse Intervention for BP Post-Stroke

Also in TTHealthWatch: cancers subsequent to CAR-T therapy

EHA over a photo of IFEMA Madrid in Spain.

Atezolizumab Consolidation Impresses in High-Risk DLBCL

Will 2-year DFS of 88%, OS of 96% renew interest in checkpoint inhibitor consolidation?

A photo of Kate Middleton

Kate Middleton Gives Cancer Update

Princess of Wales says she's making "good progress" in treatment

Adding Isatuximab to Standard Backbone Prolongs PFS in Myeloma

Joseph Mikhael, MD, leads a roundtable discussion on two positive phase III trials from ASCO

A close up photo of a woman smoking a cigarette.

Early Menopause Tied to Higher Risk of Respiratory Mortality

Greatest risk observed for women with bilateral oophorectomy

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