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AAN

Global Stroke Care Takes a Hit During the Pandemic

Seventy-country study finds ties to drop in volume of stroke hospitalizations, treatment

Blood-Based Markers Tied to Brain Cell and Memory Loss

Another step closer to clinical utility for tracking neurodegeneration

COVID Stroke Rare in ICU

Ischemic stroke in intensive care didn't raise mortality, but hemorrhagic stroke did

New-Onset Neuro Symptoms Common in Kids With MIS-C

Half of pediatric patients in small British study show neurologic involvement

Cannabis Tied to Rebound Headaches in Chronic Migraine Patients

Study adds to findings about marijuana and migraine

Alzheimer's May Start Sooner for People With Anxiety, Depression History

Psychiatric disorders could have additive effects on AD pathophysiology, study suggests

How Long Do COVID Olfactory Problems Last?

Sense of smell can be altered for 5 months or longer, Canadian study suggests

Leukemia Drug for Parkinson's: A Second Look

Are there better ways to inhibit c-Abl?

Positive Data for Novel Oral Migraine Treatment

Dual-mechanism drug shows promise in difficult-to-treat patients

Ozanimod Treatment Duration and Infection Risk

Zoster rates low, but rising with time

2019: 'The Year of NMO'

Three different drugs report lower relapse rates in neuromyelitis optica spectrum disorder

At-Home Myasthenia Gravis Therapy Shows Promise

Zilucoplan improves neuromuscular symptoms in phase II trial

Novel Drug Cocktail Offers Rare Neuropathy Patients New Hope

Charcot-Marie-Tooth patients see improved outcomes with repurposed drugs

Mixed Results with Tranexamic Acid in TBI

No benefit for neurological outcomes; some improvement in 28-day mortality rate

New Thinking on Stiff Person Syndrome -- Or Is It Syndromes?

Heterogeneity complicates the picture; rituximab, bortezomib get love for refractory cases

Oral CGRP Drug Bests Placebo for Migraine Prevention

Atogepant was effective, safe, and well-tolerated

Calcium Channel Blocker Flops in Parkinson's Disease Trial

"Disappointing" results from 3-year study don't back prior findings

Sugary Drinks May Up Disability in MS

But overall diet quality not associated with disability status

Extra Pounds May Boost Stroke Survival

Study adds to literature supporting obesity paradox

Alzheimer's Biomarker Tied to Sleep Apnea

Apnea linked to higher entorhinal cortex tau PET signal

Medical Marijuana and Older Adults

Well tolerated among elderly patients; nearly a third reduced opioids

Pro Soccer Players Show Higher ALS Risk

Incidence is rare but more frequent than expected, especially in young players

Ezutromid Shows Potential in DMD

Phase II study indicates modulating utrophin may reduce muscle inflammation

Eptinezumab Effective in Chronic Migraine

Intravenous CGRP blocker shows rapid treatment effect

Novel Endocannabinoid Modulator Improves Tics in Tourette's

In small study, total number, intensity decreased with minimal side effects, although no change for vocal tics

Oral CGRP Inhibitor Helps Relieve Migraine Attack

About 20% report being pain-free within 2 hours

Antisense Therapy Shows Promise in Huntington's

First human trial of huntingtin-lowering drug appears safe, well tolerated

Predictive Factors ID'd for Neurodegeneration in Idiopathic RBD

Opens the door to intervening with neuroprotective therapy

Retinal Abnormalities Predictor of Some Types of Stroke

Retinal imaging may offer noninvasive tool to determine pathogenesis of cerebral small vessel disease

Eyes Might ID Preclinical Alzheimer's

Presymptomatic patients show foveal thinning, retinal changes

AAN 2018: Rare Disease Breakthroughs and Novel Approaches

Noteworthy presentations at American Academy of Neurology meeting

Wrist-Worn Device Reduces Hand Tremor

Neuroperipheral therapy interrupts signal in essential tremor patients

Novel Oral Agent May Help SMA Babies

Preliminary data show SMN protein levels increasing

Erenumab Reduces Migraine in Hard-to-Treat Patients

But questions about long-term risks remain unanswered

Stringent Diet May Suppress Gluten Neuropathy

Compliance with a gluten-free diet may help the pain

Greater ALS Risk in Men Exposed to Diesel Exhaust

Findings may have implications for people living in high-traffic areas

NEPAD: Better Endpoint for Progressive MS Trials?

Tweak to 'no evidence of disease activity' standard stiffens criteria for progression

AAN Debate: Neurologists Divided on Amyloid as Alzheimer Target

Many attendees say the pathway is still worth exploring

Consistently High BP Seems to Up Dementia, AD Risk

Steep BP decrease among non-hypertensives also a concern

Presymptomatic Infants Do Best with Nusinersen

Best results may be with dosing before 6 weeks of age

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