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News, opinions and meeting coverage in neurology.

Dementia Tied to More ICD Placements

Dementia patients get more implantable cardioverter-defibrillators than expected, and even cognitively normal individuals may not understand their options about cardiac device replacement.

Anti-Amyloid Drug Has Mixed Results

COPENHAGEN -- The amyloid plaque-busting drug crenezumab for Alzheimer's disease slowed cognitive decline in patients with mild baseline impairment but missed its primary endpoint in a phase II trial.

HTN May Halt Dementia in Very Elderly

COPENHAGEN -- Among individuals who developed hypertension at age 90 or later, their risk of also developing dementia was dramatically lower than other very elderly people whose blood pressure remained normal.

APA Meeting Highlights Mental Health Biology

NEW YORK CITY -- The biological basis for normal and abnormal mental function is emerging as a dominant theme in psychiatry research, and the American Psychiatric Association annual meeting that starts here Saturday won't be an exception.

MoCA Beats MMSE to Assess Dementia

NEW ORLEANS -- The Montreal Cognitive Assessment (MoCA) was better than the Mini-Mental State Examination (MMSE) at teasing out subtle differences in cognitive performance among mildly impaired individuals, researchers reported here.

APA Leaders Defend New Diagnostic Guide

SAN FRANCISCO -- The fifth edition of the "psychiatrist's bible" was officially released here in all its 947-page glory, with its developers offering a spirited rebuttal to their critics.

DSM-5: What's In, What's Out

PHILADELPHIA -- Reports here provided what may be the last public update on DSM-5, the next edition of American psychiatry's diagnostic guide, before it is formally released in May 2013.

Brain Takes Multiple Hits from Low B12 Levels

Low levels of vitamin B12 may contribute to cognitive problems for older adults in more than one way, according to a cross-sectional study.

FDA Blocks Sale of Supplements for Parkinson's and Alzheimer's

WASHINGTON -- The FDA filed a permanent injunction against two Minnesota companies that distributed amino acid products marketed as treatments for Parkinson's disease, Alzheimer's disease, and a number of other neurological disorders.

The Top 10 Medical Advances of the Decade

From genome to hormones, doctors pick the top medical advances of the decade.

Recall of Three Little Words Helps Quick Diagnosis of Mild Cognitive Impairment

ATLANTA -- Mild cognitive impairment can be determined in less than five minutes with a three-word memory test and a clock- drawing task, according to researchers here. The words are apple, penny, and table.

Accelerated Weight Loss May Signal Imminent Dementia Onset

ST. LOUIS -- An early warning sign for Alzheimer's disease could be accelerated weight loss, found a study of aging and memory.

Blood Clots Linked to Alzheimer's and Vascular Dementias

MANCHESTER, England 芒鈧€� Spontaneous cerebral blood clots were detected at similar rates in patients with Alzheimer's disease and vascular dementia, suggesting a common pathology and a potentially preventable or treatable cause for some dementias, researchers here said.

FDA Warns of Excess Mortality to Elderly With Antipsychotics

WASHINGTON-The FDA has issued a public health advisory on the entire class of atypical antipsychotic drugs, pointing to an apparent excess of mortality for older patients with dementia, particularly when the agents are used off-label to treat behavioral disorders.