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Brain Clock Disparities; How Morphine Relieves Pain; Tolebrutinib and MS Disability

— News and commentary from the world of neurology and neuroscience

MedpageToday
Neuro Break over a computer rendering of neurons.

Brain clocks captured the diversity and and dementia in 15 countries. (Nature Medicine)

The FBI released a redacted portion of a that was one of the first to suggest the mysterious ailments were the result of "social contagion." (New York Times)

Researchers mapped out how , identifying a select set of neurons that formed a "morphine ensemble." (Science)

Electroencephalographic resembled those seen in early stages of Alzheimer's and related dementia, a systematic review showed. (Alzheimer's and Dementia)

Early treatment of a first acute myelin oligodendrocyte glycoprotein antibody-associated disease attack of a relapsing disease course. (JAMA Neurology)

The investigational Bruton's tyrosine kinase inhibitor tolebrutinib met its primary endpoint of delaying disability progression onset in a phase III study of people with (MS), but failed to reduce relapses in studies of relapsing MS versus teriflunomide (Aubagio), Sanofi said.

To date, real-life studies have not shown that like the Guardian Cap reduced brain injuries in American football, CNN reported.

The associated with SGLT-2 inhibitors -- mainly dapagliflozin (Farxiga) and empagliflozin (Jardiance) -- was less than that with DPP-4 inhibitors in people with type 2 diabetes, according to Korean data. (The BMJ)

Cholinesterase inhibitors slowed cognitive decline over 5 years in people who had compared with both nonuse and memantine (Namenda), Swedish registry data showed. (Alzheimer's and Dementia)

A phase III trial showed that the orexin receptor antagonist suvorexant (Belsomra) in older adults at high risk for delirium after hospitalization. (JAMA Network Open)

  • Judy George covers neurology and neuroscience news for 鶹ý, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more.