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News, opinions and meeting coverage in psychiatry.

DSM-5: What's In, What's Out

PHILADELPHIA -- Reports here provided what may be the last public update on DSM-5, the next edition of American psychiatry's diagnostic guide, before it is formally released in May 2013.

DSM-5 Panel Tiptoes on Grief, Depression

PHILADELPHIA -- Psychiatrists writing new diagnostic criteria for major depression hope an explanatory note will mollify critics of a proposal to let patients grieving a dead loved one receive a formal diagnosis.

Most DSM-5 Revisions Pass Field Trials

PHILADELPHIA -- Field trials of proposed new diagnostic criteria for many mental disorders showed that, for the most part, they were at least adequately reliable.

Antidepressants May Help Cut Seizures

NEW ORLEANS -- Patients with epilepsy who experience more than one seizure a month appear to achieve a reduction in seizure activity when treated with antidepressants, researchers reported here.

ADHD Drug Helpful in Adult Depression

Phase II trial results suggested that a stimulant drug approved to treat attention deficit-hyperactivity disorder may improve cognitive function in adults with major depression, its manufacturer said.

Use of Psych Drugs Up, Women Biggest Users

One American in five takes psychiatric medication for conditions such as depression and anxiety, and use of the drugs is more common among women, researchers found.

Linezolid Toxic With Prozac, Other SSRIs, FDA Warns

The FDA has issued an updated statement on the potential for serious central nervous system toxicity when patients taking serotonergic psychiatric drugs are treated with the antibacterial agent linezolid (Zyvox).

FDA Warns Against High-Dose Citalopram

Citing increased risk of cardiac arrhythmias and a lack of therapeutic benefit associated with high doses of the SSRI citalopram hydrobromide (Celexa), the FDA has reduced the recommended maximum to 40 mg/day.

Lab Notes: Red Wine Before Radiation and Red Clover for Hair Loss

Red is the color of the day, as components of red wine and red clover lead this week's Lab Notes, but the blues get their turn in the spotlight, too, as depressed people outshine cheerier folks in some elements of decision making.

FDA Panel: Keep ECT Devices as High Risk

GAITHERSBURG, Md. -- The FDA should continue to regulate electroconvulsive therapy (ECT) machines as high-risk devices for treating depression and most other conditions for which ECT is typically used, members of the agency's Neurological Devices Advisory Committee agreed.

FDA Panel Looks at Trials of Devices to Treat Depression

GAITHERSBURG, Md. -- An FDA advisory panel met Friday to discuss how to analyze trials designed to test devices used to treat depression, but didn't offer the FDA any clear-cut guidance.

Mild Mania Often Accompanies Major Depression

A high proportion of people with major depression may actually have a "hidden" form of bipolar disorder, according to a population-based study.

Antidepressants Not Recommended for Autism

Selective serotonin reuptake inhibitors (SSRIs) can't be recommended for treating autism in children or adults at this point, according to a Cochrane review.

Five SSRIs Endorsed as Effective for Obsessive Compulsive Disorder

LONDON -- Five antidepressants given for obsessive compulsive disorder all seem to confer twice the likelihood of modest symptom relief compared with placebo, found a systematic review.

Virginia Tech Missed 'Clear Warnings' of Shooter's Mental Instability

RICHMOND, Va. -- The Virginia Tech massacre might have been prevented if university authorities had heeded "clear warnings of mental instability" from the shooter, found a state review panel.

APA: Simple Screen Improves Suicide Risk Assessment

SAN DIEGO -- Emergency department patients who may be suicidal can be identified with a simple tool designed for use by health professionals without a mental health background.

APA: Abilify Has Adjunctive Antidepressant Effect

SAN DIEGO -- Aripiprazole (Abilify) may be a useful adjunctive therapy in patients with major depressive disorders who have incomplete responses to antidepressants, researchers reported here.

USPSYCH: Insomnia Treatment Boosts Antidepressant Efficacy

SAN FRANCISCO -- A significant number of patients with major depression also suffer from chronic insomnia that hampers recovery, and treating the insomnia may improve both conditions.

Grief Following Death in the Family Ebbs in Six Months

NEW HAVEN -- The negative emotions of grief -- yearning, depression, and anger -- following the death of a family member from natural causes usually peak within six months, according to a Yale bereavement study of 233 mourners

FDA Warns on Mixing Antidepressants with Migraine Drugs

ROCKVILLE, Md. -- Mixing common migraine drugs such as Imitrex (sumatriptan) with antidepressants like Prozac (fluoxetine) or Cymbalta (duloxetine) can trigger a life-threatening condition called serotonin-syndrome, the FDA has warned.

FDA Approves First Antidepressant Transdermal Patch

ROCKVILLE, Md. - The FDA has approved a once-a-day antidepressant patch that delivers a monoamine oxidase inhibitor. Called Emsam (selegiline), the patch can be used at its lowest dose without the dietary restrictions that accompany oral MAO inhibitors.

Acetaminophen Is Leading Cause of Acute Liver Failure

SEATTLE - Deliberate or inadvertent overdosing with acetaminophen (Tylenol and generics) is the leading cause of acute liver failure in the United States, researchers reported.

Suicide Risk Rises for Shorter Men

UPPSALA, Sweden-Shorter men have a twofold greater risk of suicide than taller men, according to a cohort study of more than a million men in this country.

A Child's Death Increases Parents' Risk of Mental Illness

LOS ANGELES-When a child dies, grieving parents have an increased risk of first diagnosis of serious mental illness such as clinical depression or bipolar disorder.

St. John's Wort Better than SSRI for Moderate to Severe Depression

A study published in The British Medical Journal found that a herbal extract of St. John's wort was at least as effective as Paxil(R) (paroxetine) and had fewer side effects in patients with moderate to severe depression.

Provigil (modafinil) Counteracts SSRI Side Effects

Provigil 脗庐 (modafinil) not only counteracted the excessive fatigue and somnolence experienced by some patients on selective serotonin reuptake inhibitors (SSRIs), but also improved mood and quality of life in this patient group, according to a preliminary study published in the Journal of Clinical Psychiatry.