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General Rheumatology

News, opinions and meeting coverage in rheumatology.

A Cure for Chlamydia Arthritis?

Increased understanding of the biology and survival tactics of Chlamydia trachomatis is suggesting that the post-infectious chronic arthritis experienced by many patients may actually be curable.

Rituxan Offers Little Help for Sjogren's

Treatment for primary Sjogren's syndrome with the B-cell depleting antibody rituximab (Rituxan) failed to provide statistically significant improvements, despite the increasing evidence for B cells in the pathogenesis of this disorder, French researchers reported.

Neuropathy May Signal Lupus

Peripheral neuropathy is a more common manifestation of systemic lupus erythematosus than has been previously appreciated, and often is a small-fiber neuropathy affecting the dorsal root ganglia, a large retrospective study found.

High IgG Signals Autoimmunity in Kids

High levels of immunoglobulin G (IgG) in children -- and particularly girls -- were associated with the development of autoimmune disease, researchers found.

Autoantibodies a Big Deal in Sjogren鈥檚

SAN DIEGO -- A broader range of autoantibodies may play a role in Sjogren's syndrome than has previously been appreciated, researchers found.

Mom's Lupus Tied to Child's Autism

SAN DIEGO -- Children born to mothers with systemic lupus erythematosus have twice the risk for autism spectrum disorders as those whose mothers are unaffected, a Canadian researcher reported here.

Antidepressants, Lyrica OK Combo in Fibromyalgia

SAN DIEGO -- Patients with fibromyalgia who were taking antidepressants found that their pain was successfully managed with pregabalin (Lyrica), a researcher said here.

Few Lupus, IBD Patients Getting HPV Vaccine

SAN DIEGO -- Despite being at greater risk of infection, few children and young adults with autoimmune diseases are being vaccinated against human papillomavirus, according to a study.

FDA Panel Nixes Humira for Spinal Arthritis

SILVER SPRING, Md. -- An independent panel of FDA advisers overwhelmingly rejected AbbVie's bid to gain approval of Humira (adalimumab) for treatment of spinal arthritis.

Sjogren's Carries Heavy Disease Burden

BIRMINGHAM, England -- Patients with primary Sjogren's syndrome are prone to develop serious complications over the long term, despite the presumption that this is a relatively benign autoimmune disease, a 25-year review found.

TB No Barrier to Anti-TNF Treatment

WASHINGTON -- Patients being treated with tumor necrosis factor inhibitors who develop tuberculosis may safely reinstitute their biologic before completing the lengthy TB treatment regimen, a retrospective study suggested.

Food Allergy Common in Joint Disorder

ORLANDO -- Children with the inherited disorder known as Ehlers Danlos type 3 syndrome may be at high risk for severe food allergy, British researchers reported here.

ACR: Savella Brings Relief Long-Term in Fibromyalgia

CHICAGO -- Milnacipran (Savella), a selective serotonin and norepinephrine reuptake inhibitor, brought long-term relief to fibromyalgia patients who remained on therapy, researchers said here.

Sjogren's Sidelines Venus Williams

When women's tennis star Venus Williams withdrew from the U.S. Open this week, she brought immediate attention to the little-known autoimmune disease Sjögren's syndrome, thought to afflict some 0.5% of adults.

Enzyme Works for Hard-to-Treat Gout

The intravenous enzyme pegloticase (Krystexxa) is an effective therapy for many people whose gout doesn't respond to conventional treatment, researchers reported.

Raynaud's Responds to Erectile Dysfunction Drug

The erectile dysfunction drug sildenafil (Viagra) may also help treat Raynaud's phenomenon, one of the most common complications of limited cutaneous systemic sclerosis.

ACR: Drinking Water May Wash Away Gout Attacks

PHILADELPHIA -- A half-gallon of drinking water a day may keep gout attacks away, researchers said here.

Herniated Disc Surgery Found Cost-Effective

HANOVER, N.H. -- For patients with a herniated disc, surgery proved a cost-effective alternative to nonsurgical treatment over the course of two years, an observational study found.

Oral Prednisolone and Naproxen (Aleve) Equal for Gout Pain

NIJMEGEN, The Netherlands, May 29 -- For the acute pain of monoarticular gout over four days, it's a tossup between oral prednisolone and naproxen (Aleve), a randomized trial found.

Flovent Edges Oral Prednisone for Eosinophilic Esophagitis

INDIANAPOLIS -- Swallowed fluticasone spray (Flovent) may be a better choice for allergic eosinophilic esophagitis in children, researchers here said.

Scleroderma Patients Are Living Longer

WASHINGTON -- The lifespan for patients with scleroderma has increased significantly since the 1970s, in large measure because of a decline in deaths from renal disease.

Gabapentin (Neurontin) Eases Chronic Pain in Fibromyalgia

CINCINNATI -- For treating the chronic pain and other symptoms of fibromyalgia, the anticonvulsant gabapentin (Neurontin) proved safe and effective, researchers here reported.

High-Dose Steroids Linked to Risk of Atrial Fibrillation

ROTTERDAM, The Netherlands 芒鈧€� High dose corticosteroid therapy may increase the risk of atrial fibrillation, researchers here reported.