Off-the-Shelf T-Cell Therapy Effective Against Viral Infections After Allo-HCT Produced an antiviral response in 95% of patients with six different types of infection Jan 13, 2023
MRI-Guided Focused Ultrasound Eases Pain From Bone Metastases More responses with ultrasound, but quality-of-life scores lower vs EBRT in nonrandomized trial Jan 11, 2023
Study Supports Routine Omentectomy in Absence of Metastasis During CRS-HIPEC High rate of occult metastases in patients with grossly normal omentum Jan 11, 2023
Bariatric Surgery May Reduce Risk of Esophageal, Gastric Cancers Cohort study provides "reassurance of the protective clinical benefits of weight loss surgery" Jan 11, 2023
Zanubrutinib Shows Good Tolerance in BTK-Inhibitor Intolerant Malignancies Most patients had no recurrence of their original intolerance event Jan 10, 2023
Post-HSCT Brentuximab Vedotin Plus Nivolumab Highly Effective in Hodgkin Lymphoma However, toxic effects might limit the combination to the highest-risk patients Jan 10, 2023
Conspiracy Theorists' Cancer Beliefs; HIV Meds and Ethnicity Also in TTHealthWatch: sodium levels and health outcomes Jan 07, 2023 podcast
Genomic Assay May Pinpoint Who Can Skip RT After Breast-Conserving Surgery Patients categorized as low risk with 16-gene signature showed no significant benefit with RT Jan 06, 2023
More Evidence to Support Restrictive Opioid Prescribing After Cancer Surgery Significant decreases in prescription days, doses, refill requests, with few patient complaints Jan 06, 2023
Optimizing Treatment for Older Patients With HR+ Low-Risk Breast Cancer Five days of radiotherapy, five years of hormonal therapy, or somewhere in between? Jan 05, 2023
More Extensive Resection of Low-Grade Glioma Linked to Longer Survival Across both subtypes, improved survival seen with at least 75% resection, study finds Jan 05, 2023
Watch for New Psych Disorders in the Spouses of Cancer Patients Risk especially high within the first year after cancer diagnosis Jan 05, 2023
Jazz Musician With Slowly Expanding Neck Mass Causing Dysphagia Alcoholism, liver dysfunction highly linked with rare disease of unknown etiology Jan 04, 2023
Can Dying Well Be a Part of Living Well? Shoshana Ungerleider, MD, on her mission to transform end-of-life care Jan 03, 2023 podcast
Crystal Ball Cloudy for PI3K Inhibitors' Future in Hematology After a year of negative news, some caution about throwing out the baby with the bath water Jan 02, 2023
Adagrasib Shows Anti-Tumor Activity in Heavily Pretreated KRAS-Mutant CRC Response rates of 19% alone, 46% with cetuximab in phase I/II trial Dec 21, 2022
Early Win for Gene Therapy in Rare Form of SCID 10 infants were able to make their own T cells; safety good so far Dec 21, 2022
Mixed Results With Hormonal Strategies for Premenopausal Breast Cancer Exemestane reduced recurrence, metastasis versus tamoxifen, but no survival benefit Dec 20, 2022
Long-Term Data Reinforce Targeted Combo Versus Single Agent for Advanced Melanoma Encorafenib-binimetinib tops vemurafenib, but checkpoint inhibitors remain first-line choice Dec 19, 2022
OS Benefit Eludes Second-Line Niraparib Maintenance in Ovarian Cancer Significant PFS results demonstrated in NORA trial don't extend to overall survival Dec 17, 2022
FDA Approves First Gene Therapy for Non-Muscle-Invasive Bladder Cancer Half of patients achieved complete responses with adenoviral vector-based product Dec 16, 2022
Anti-PD-1 Drugs Impress as Frontline Therapy for Early, Unfavorable Hodgkin's 3-year PFS of 99%, OS of 100% with nivolumab-chemo, high response rate with pembrolizumab Dec 16, 2022
No Blaming Common Antihypertensives for Pancreatic Cancer, Study Suggests Some reassurance on widely prescribed dihydropyridine calcium channel blockers Dec 15, 2022
New Regimen for GvHD Prophylaxis in Well-Matched Reduced-Intensity Allo-HCT Post-transplant cyclophosphamide, tacrolimus, and MMF reduces GvHD without higher relapse risk Dec 14, 2022
'Practice-Changing' Results With Zanubrutinib Versus Ibrutinib in CLL/SLL Significantly longer PFS with second-gen BTK inhibitor in relapsed/refractory disease Dec 14, 2022
C3 Pathway Inhibitor May Change Practice for Paroxysmal Nocturnal Hemoglobinuria Iptacopan improved hemoglobin without transfusion versus current standard of care Dec 14, 2022
High-Dose Chemo, ASCT Improves Survival in Primary CNS Lymphoma European trial is "practice-changing as of today," says U.S. expert Dec 13, 2022
Prolonged Responses in DLBCL Spark Talk of a Cure With Bispecific Antibody Most complete responses lasted 24 months or longer after limited-duration glofitamab Dec 13, 2022
Blinatumomab-Chemo Consolidation a 'New Standard' in MRD-Negative B-ALL Phase III study showed 58% reduction in the risk of death versus chemo alone Dec 13, 2022
Pediatric Hodgkin Lymphoma Survivors Experience Accelerated Epigenetic Aging Data from St. Jude cohort show higher rates of neurocognitive impairment Dec 13, 2022
Direct-Acting Antivirals Linked to Improved Outcomes in Chronic Hepatitis C All-cause mortality rate significantly lower in treated versus untreated group Dec 13, 2022
Durable Platelet Response in Immune Thrombocytopenia With Efgartigimod Glycoprotein receptor inhibitor produces four times as many responses as placebo Dec 12, 2022
Black Patients Less Likely to Get Advanced Treatments for PE Also less likely for patients on Medicare and Medicaid Dec 12, 2022
AML Study Suggests Intensive Chemo Unnecessary Before Allo-HCT Similar outcomes if patients went directly to transplant or received intensive salvage first Dec 11, 2022
Talquetamab Offers New Hope in Relapsed/Refractory Multiple Myeloma Bispecific antibody achieves "incredible" response rates over 70% in heavily pretreated patients Dec 11, 2022
Ibrutinib Makes Its Case for First-Line Treatment in Mantle Cell Lymphoma Standard-of-care autologous transplant fails to prove superior to BTK inhibitor alone Dec 11, 2022
Rigid In-Hospital Diet Offers No Advantage in Patients After HSCT "We should eliminate these silly neutropenic diets," expert says Dec 10, 2022
Higher Brain Cancer Risk After CT Exam in Childhood Study suggests one radiation-induced brain cancer expected per 10,000 persons receiving a head CT Dec 09, 2022
Less Is More Wins Again: Avoiding Node Dissection in Early Breast Cancer First comparison of targeted sentinel node assessment shows no difference in recurrence rates Dec 09, 2022
Adding AKT Inhibitor Doubles PFS in Advanced, HR-Positive Breast Cancer In phase III trial, capivasertib benefited patients with or without AKT pathway alterations Dec 09, 2022
