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Alzheimer's Disease

News, opinions and meeting coverage in neurology.

FDA APPROVED Lecanemab-irmb (Leqembi) over a computer rendering of amyloid plaques forming between neurons

Alzheimer's Drug Lecanemab Wins FDA Approval

Anti-amyloid showed modest benefit in phase III trial, but was linked to adverse events

A photo of a mature woman wearing headphones during a hearing test in a sound proof booth.

Earlier Health Conditions Tied to Subsequent Dementia

Alzheimer's disease, vascular dementia links are time-dependent

A computer rendering of a person鈥檚 transparent head with a cerebral hemorrhage highlighted

Scattered Brain Bleeds, Vasculitis in Alzheimer's Trial Death

Case report is published days ahead of FDA lecanemab decision

A computer rendering of aggregations of tau proteins causing disintegration of a microtubule

Novel Blood Test Detects Alzheimer's Neurodegeneration

Brain-derived tau distinguished Alzheimer's from other dementias

A photo of a mature man using two mirrors to see his bald spot.

5-ARIs Not Linked to Risk of Dementia Over the Long Term

However, finasteride and dutasteride were associated with an increased risk of depression

A computer rendering of the molecular model of calcifediol over a human brain.

Brain Vitamin D Tied to Cognitive Function

No links seen with Alzheimer's or dementia pathology, however

A photo of a mature, bearded man wearing a cochlear implant

Use It, or Lose It: Hearing Aids Linked to Cognitive Benefit

Treating hearing loss makes a difference, meta-analysis suggests

A photo of Chris Hemsworth

Chris Hemsworth's APOE4 Alzheimer's Gene

The Thor actor recently learned about his genetic predisposition

A computer rendering of nerve cells affected by Alzheimer鈥檚 disease.

Second Trial Participant Dies in Alzheimer's Drug Study

"All eyes are on lecanemab," a closely watched anti-amyloid treatment

A photo of a mature man struggling to remember something.

Dementia Signs Emerge Up to 9 Years Before Diagnoses

Cognitive, functional changes spotted in pre-Alzheimer's patients and others

A photo of a mature couple chopping vegetables in the kitchen.

Does Diet Matter? Study Questions Links Between Diet and Dementia

Diet combined with other risk-reduction strategies may show different results

AAO over a photo of McCormick Place in Chicago, Illinois

AAO Roundup: Glaucoma Subtype Linked to Alzheimer's Disease Risk

Other studies report fewer reoperations with combo eye surgery and vision risk with shingles

A photo of the packaging and blisterpacks of Cialis and Viagra over a computer rendering of amyloid plaques.

Can Erectile Dysfunction Drugs Reduce Dementia Risk?

DREAM study findings conflict with other recent data

A photo of a worried looking mature man with his head in his hands.

Dementia Diagnosis Linked to Suicide

Risk almost seven times higher for people with diagnosis before age 65

Psych Congress over a photo of the Ernest N. Morial Convention Center in New Orleans, Louisiana

Rexulti Calms Alzheimer's Dementia-Related Agitation

But atypical antipsychotic disappoints in borderline personality disorder

A photo of a man with down syndrome working in a factory.

Hormone Treatment Improves Cognition in Down Syndrome

Pulsatile GnRH therapy boosted brain connectivity in pilot study

A computer rendering of a herpes virus.

Herpes Viruses Linked to Brain Changes

But no evidence of a relationship between herpes and Alzheimer's disease

AAIC over a photo of the San Diego Convention Center in California.

Alzheimer's Researchers Delve Into Data From Failed Crenezumab Trial

Anti-amyloid agent missed primary endpoints, though small numeric differences favored the drug

AAIC over a photo of the San Diego Convention Center in California.

Alzheimer's Blood Tests: Not Ready for Primary Care

But some biomarkers may revolutionize Alzheimer's diagnosis in the future

AAIC over a photo of the San Diego Convention Center in California.

Hypertensive Disorders in Pregnancy Linked to Dementia Later in Life

Women saw higher risks of all-cause dementia and vascular dementia

AAIC over a photo of the San Diego Convention Center in California.

Racism Experiences Tied to Worse Cognition

Links between racism and memory seen in both midlife and old age

AAIC over a photo of the San Diego Convention Center in California.

ICU Stay Doubles Dementia Risk

Higher risks of both Alzheimer's and all-type dementia seen

AAIC over a photo of the San Diego Convention Center in California.

Biomarkers Show Who Faces Near-Term Cognitive Decline

Consistent findings emerge in four groups of cognitively normal adults

A photo of an Asian man holding up a piece of deep fried chicken.

Dementia Risk Climbs With Intake of Ultra-Processed Foods

Swapping out ultra-processed for unprocessed or minimally processed foods can lower risk sharply

INVESTIGATIVE ROUNDUP over an image of two people looking at computer screens.

Doctored Images, Fake Data, Plagiarism: Scandals Rock Alzheimer's, Cancer Research

This past week in healthcare investigations

A photo of a senior couple speed walking on a promenade.

Physical Exercise Tied to Greater Cognitive Reserve in Women

Both men and women see benefit from mentally stimulating activities

Brain scan images with NeuroBreak in the center.

Alzheimer's-Gut Links; Long COVID and ME/CFS; ALS Patient Gets Novel Brain Interface

News and commentary from the world of neurology and neuroscience

A photo of audio waveforms as seen on a computer monitor

Voice Recordings Spot Cognitive Impairment

Machine-learning model discerns normal cognition, mild cognitive impairment, and dementia

A computer rendering of a neuron releasing neurotransmitters.

ADHD Drugs May Treat Alzheimer's Cognitive Symptoms Effectively

Positive effect on global cognition, apathy in meta-analysis

Brain scan images with NeuroBreak in the center.

Hot Human Brains; LATE Prevalence Revealed; Novel ALS Drug Wins Canadian Approval

News and commentary from the world of neurology and neuroscience

A photo of a normal brain next to a brain with advanced CTE.

Evidence of CTE Rare in Military Personnel

Limited number of cases preclude causal conclusions

SLEEP over a photo of the Charlotte Convention Center in North Carolina

Unstable Sleep Patterns Linked With Worsening Cognition

Longitudinal data put sleep variability in a negative light

A motion blurred photo of a senior man walking and a young boy running on a city sidewalk.

Walking Speed Helps Predict Future Dementia

Dual decline in gait speed and cognition tied to higher dementia risk

A graphic from the American Heart Association of Life鈥檚 Simple 7.

Even With High Genetic Risk for Alzheimer's, Lifestyle Factors Matter

Midlife scores on Life's Simple 7 tied to dementia incidence across a range of genetic profiles

A computer rendering of a transparent brain with the choroid plexus highlighted.

Alzheimer's, Cognitive Impairment Linked With Choroid Plexus Volume

Blood-CSF barrier may play a role in Alzheimer's pathogenesis

A photo of a senior man eating a hot dog at a country fair.

Brain Aging Markers Tied to Inflammatory Foods

Smaller brain volume seen with diet-driven inflammation

A close up rubber gloved hands collecting cerebrospinal fluid with a vial from a spinal needle

Can Young Cerebrospinal Fluid Boost Cognition?

Brain fluid from young mice improved memory in older ones

FDA APPROVED Lumipulse G 尾-Amyloid Ratio (1-42/1-40) test over a computer rendering of amyloid plaques around neurons.

Early Alzheimer's Test Gets FDA Nod

First in vitro diagnostic to detect amyloid in early disease setting

A close up of a woman鈥檚 hand gnarled by arthritis resting on the head of a cane.

Is Alzheimer's Risk Lower With TNF Inhibitors?

For arthritis patients with cardiovascular disease, the answer may be yes

A photo of a man鈥檚 hand with IV line attached and the vial and packaging of Aduhelm

Medicare Finalizes Limits on Aducanumab Coverage

But decision allows flexibility for some anti-amyloid Alzheimer's drugs

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