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Alzheimer's Disease

News, opinions and meeting coverage in neurology.

AAN over a photo of the Washington State Convention Center, Seattle, WA.

Memory Enhancer Succeeds in Phase II Alzheimer's Trial

Novel NMDA-targeted drug would expand options for symptomatic treatment

A photo of the vial and packaging of Aduhelm.

Aducanumab Data Finally Published, but Alzheimer's Experts Spot Problems

Questions raised about secondary endpoints

Brain scan images with NeuroBreak in the center.

Cialis and Brain Blood Flow; Sleep and Media Use; Can Tarantulas Solve Chronic Pain?

News and commentary from the world of neurology and neuroscience

A cross section slice of a brain with Alzheimer鈥檚 disease

COVID Brain Changes Show Parallels With Alzheimer's Disease

Findings may point to potential mechanism for brain fog in people with long COVID

The packaging and vial of Aduhelm over a close up of a Medicare card

Medicare Plans to Restrict Coverage of New Alzheimer's Drug

Proposal would cover aducanumab (Aduhelm) in patients on qualifying clinical trials

An illustration depicting Alzheimer鈥檚 disease with amyloid plaques forming between neurons

Alzheimer's Drugs Race to FDA

After aducanumab, drug companies pivot to use the accelerated approval pathway

A photo of Viagra pills blister pack and packaging.

Can Viagra Prevent Alzheimer's?

Sildenafil shows potential for drug repurposing

The vial and packaging of Aduhelm (aducanumab) over a close up of a man鈥檚 hand with IV attached.

Let Ethics Guide Aducanumab Prescribing, AAN Says

Don't rely on FDA approval alone to make best choices for Alzheimer's patients

Brain scan images with NeuroBreak in the center.

Alzheimer's Plasma Exchange; Fish Intake and Brain Health; HIV Neuropathy

News and commentary from the world of neurology and neuroscience

An MRI image of a brain with Alzheimer鈥檚 disease.

One Aducanumab Patient, Six Brain Edema Episodes

"Uniquely complicated course" for patient treated with new Alzheimer's drug

I'm a Neurologist With Alzheimer's

How knowledge helps the uncertainty

Brain scan images with NeuroBreak in the center.

HCQ and MS; Guillain-Barre and COVID Vax; Neural Fingerprints Can Tell Who You Are

News and commentary from the world of neurology and neuroscience

Brain scan images with NeuroBreak in the center.

TikTok Tics; COVID Vaccines and CVST; Predicting Brain Injury Outcomes

News and commentary from the world of neurology and neuroscience

EASD over an illustration of a person's hand and blood glucose monitor and other icons associated with diabetes.

Healthy Lifestyle Keeps Dementia at Bay in Patients With Diabetes

Maintaining control of risk factors neutralized excess dementia risk

Brain scan images with NeuroBreak in the center.

Guillain-Barr茅 and COVID; Head-to-Head Alzheimer's Blood Tests; Fastball EEG

News and commentary from the world of neurology and neuroscience

The packaging and blister packs of Ritalin (methylphenidate)

Stimulant Reduces Apathy in Alzheimer's Disease

Twice daily methylphenidate showed modest effect size

A close up of a man's white rubber gloved hand picking up a bullet shell from the floor with tweezers.

Preventing Gun Violence in Patients With Dementia

Gun safety advocate Emmy Betz, MD, MPH, offers advice

A computer rendering of beta-amyloid protein forming plaques and collecting between neurons.

Amyloid Tipping Point Helps Predict Alzheimer's Dementia Onset

Algorithm requires only one PET scan and age

Feared ARNI Effect on Cognition Hasn't Come to Fruition

Neurocognitive protection by sacubitril/valsartan suggested instead by observational study

A computer rendering of a heart cross section with implanted left ventricular assist device

Some Reassurance on Cognition in People With Older LVADs

Will newer devices look even better for neurological outcomes?

A technician prepares blood samples for mass spectrometry

Blood Test Discerns Alzheimer's From Other Dementia With High Accuracy

Plasma p-tau moves another step closer to clinical use

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Driving Patterns Pinpoint Early Alzheimer's Disease

Subtle shifts in on-road behavior suggest GPS-based biomarkers may have merit

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

COVID-19: Persistent Cognitive Effects, Uptick in Alzheimer's Biomarkers

Findings link cognitive impairment and long-lasting anosmia

INVESTIGATIVE ROUNDUP over an image of two people looking at computer screens.

Epic's AI Fail; Controversial Alzheimer's Marketing; No Good COVID Drugs

This past week in healthcare investigations

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Aducanumab: What to Know If You Prescribe

Recommendations may change when trial data are published

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Better Air, Better Brains

Reducing air pollution tied to lower dementia risk, slower cognitive decline

A stressed looking senior woman next to a bottle of Nuplazid (pimavanserin) capsules.

Staying on Pimavanserin Cut Dementia-Related Psychosis Relapse

However, late-stage trial couldn't separate efficacy in dementia subtypes

A senior woman talks on her smartphone at home.

Phone Calls Spot Early Alzheimer's

Predictive model identified vocal features of dementia patients from everyday speech

The YouTube video thumbnail with Dr. Zubin Damania and Vinay Prasad, MD, MPH, and the words IVERMECTIN& Aducanumab?

Ivermectin and Aducanumab: Do They Work?

ZDoggMD and Vinay Prasad, MD, MPH, analyze the evidence

The vial and packaging of Aduhelm (aducanumab) for injection with blurred prescribing information in the background.

Alzheimer's Aducanumab Prescribing Information Changes

"We as neurologists need a strategy to advise our patients," experts say

A chart showing estrogen levels in a female silhouette from age 25-80

Alzheimer's Biomarkers Tied to Endogenous Estrogen Exposure in Women

Longer reproductive period linked to amyloid, p-tau in cognitively normal older women

A mature person with Down syndrome draws in an activity book.

APOE Gene Influences Alzheimer's Symptoms, Biomarkers in Down Syndrome

Earlier Alzheimer's changes seen in APOE4 carriers

A computer rendering of the release of cytokines.

Two Inflammatory Proteins Linked With Slower Cognitive Decline

Surprise finding ties plasma cytokine levels with Alzheimer's biomarkers and cognition

An FDA APPROVED seal over a photo of prescription bottles on a shelf

The FDA Is Failing the American People

The agency's recent decision to approve aducanumab offers more evidence of a broken system

A microscopy of Neurofibrillary tangles in the Hippocampus of an old person with Alzheimer-related pathology.

Alzheimer's Tau Vaccine Shows Immune Response, Safety

Exploratory, post hoc analyses hint at plasma NfL changes, and in some, slower cognitive decline

A photo collage of a wall clock and a portrait of a senior man staring into space and disintegrating into particles.

Cognitive Clock Predicts Brain Health

Brain age forecasts outcomes better than chronological age

A computer rendering of phosphorylation of tau proteins

Simple Tool Predicts Individual Alzheimer's Risk

Blood and quick cognitive tests boost accuracy to 90%

A photo of Daniel Gibbs, MD, PhD, next to his book A Tattoo on My Brain

A Neurologist Faces His Alzheimer's Disease

"I'm in the ring with the tiger," says Daniel Gibbs

A computer rendering of beta-amyloid protein clumping and tau protein accumulating in a brain with Alzheimer鈥檚 disease.

Defining Alzheimer's: Should Cognitively Unimpaired People Be Included?

A definition that works for research is not right for the clinic, experts argue

APA over an illustration of a red hand pulling a tangled thread from a woman鈥檚 head

Dissolving Film Quells Agitation in Schizophrenia, Bipolar Disorder

Improvements seen in 30 minutes or less with investigational oral agent

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