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Alzheimer's Disease

News, opinions and meeting coverage in psychiatry.

A photo of a man with down syndrome working in a factory.

Hormone Treatment Improves Cognition in Down Syndrome

Pulsatile GnRH therapy boosted brain connectivity in pilot study

A computer rendering of a herpes virus.

Herpes Viruses Linked to Brain Changes

But no evidence of a relationship between herpes and Alzheimer's disease

Illustration of a brain shaped maze.

KarXT Schizophrenia Win; CBD for Anxiety; No Nuplazid for Alzheimer's Psychosis

News and commentary from the psychiatry world

AAIC over a photo of the San Diego Convention Center in California.

Alzheimer's Researchers Delve Into Data From Failed Crenezumab Trial

Anti-amyloid agent missed primary endpoints, though small numeric differences favored the drug

AAIC over a photo of the San Diego Convention Center in California.

Alzheimer's Blood Tests: Not Ready for Primary Care

But some biomarkers may revolutionize Alzheimer's diagnosis in the future

AAIC over a photo of the San Diego Convention Center in California.

Hypertensive Disorders in Pregnancy Linked to Dementia Later in Life

Women saw higher risks of all-cause dementia and vascular dementia

AAIC over a photo of the San Diego Convention Center in California.

Racism Experiences Tied to Worse Cognition

Links between racism and memory seen in both midlife and old age

AAIC over a photo of the San Diego Convention Center in California.

ICU Stay Doubles Dementia Risk

Higher risks of both Alzheimer's and all-type dementia seen

AAIC over a photo of the San Diego Convention Center in California.

Biomarkers Show Who Faces Near-Term Cognitive Decline

Consistent findings emerge in four groups of cognitively normal adults

A photo of an Asian man holding up a piece of deep fried chicken.

Dementia Risk Climbs With Intake of Ultra-Processed Foods

Swapping out ultra-processed for unprocessed or minimally processed foods can lower risk sharply

INVESTIGATIVE ROUNDUP over an image of two people looking at computer screens.

Doctored Images, Fake Data, Plagiarism: Scandals Rock Alzheimer's, Cancer Research

This past week in healthcare investigations

A photo of a senior couple speed walking on a promenade.

Physical Exercise Tied to Greater Cognitive Reserve in Women

Both men and women see benefit from mentally stimulating activities

A photo of audio waveforms as seen on a computer monitor

Voice Recordings Spot Cognitive Impairment

Machine-learning model discerns normal cognition, mild cognitive impairment, and dementia

Illustration of a brain shaped maze.

Promising New Depression Tx; Racially Skewed ADHD Dx; Effective Clozapine Monitoring

News and commentary from the psychiatry world

A computer rendering of a neuron releasing neurotransmitters.

ADHD Drugs May Treat Alzheimer's Cognitive Symptoms Effectively

Positive effect on global cognition, apathy in meta-analysis

A photo of a normal brain next to a brain with advanced CTE.

Evidence of CTE Rare in Military Personnel

Limited number of cases preclude causal conclusions

SLEEP over a photo of the Charlotte Convention Center in North Carolina

Unstable Sleep Patterns Linked With Worsening Cognition

Longitudinal data put sleep variability in a negative light

A motion blurred photo of a senior man walking and a young boy running on a city sidewalk.

Walking Speed Helps Predict Future Dementia

Dual decline in gait speed and cognition tied to higher dementia risk

A graphic from the American Heart Association of Life鈥檚 Simple 7.

Even With High Genetic Risk for Alzheimer's, Lifestyle Factors Matter

Midlife scores on Life's Simple 7 tied to dementia incidence across a range of genetic profiles

A computer rendering of a transparent brain with the choroid plexus highlighted.

Alzheimer's, Cognitive Impairment Linked With Choroid Plexus Volume

Blood-CSF barrier may play a role in Alzheimer's pathogenesis

A photo of a senior man eating a hot dog at a country fair.

Brain Aging Markers Tied to Inflammatory Foods

Smaller brain volume seen with diet-driven inflammation

A close up rubber gloved hands collecting cerebrospinal fluid with a vial from a spinal needle

Can Young Cerebrospinal Fluid Boost Cognition?

Brain fluid from young mice improved memory in older ones

Illustration of a brain shaped maze.

FDA Clears TMS for OCD; Cerebral Pauses ADHD Scripts; Binge-Eating Drug Flops

News and commentary from the psychiatry world

FDA APPROVED Lumipulse G 尾-Amyloid Ratio (1-42/1-40) test over a computer rendering of amyloid plaques around neurons.

Early Alzheimer's Test Gets FDA Nod

First in vitro diagnostic to detect amyloid in early disease setting

Illustration of a brain shaped maze.

Dr. Fryer's Legacy; Zuranolone Starts Approval Process; Alzheimer's Vax Fast-Tracked

News and commentary from the psychiatry world

Illustration of a brain shaped maze.

New Caplyta Doses OK'd; ECT Effective Against Suicide; Antidepressants Flop for QoL

News and commentary from the psychiatry world

A close up of a woman鈥檚 hand gnarled by arthritis resting on the head of a cane.

Is Alzheimer's Risk Lower With TNF Inhibitors?

For arthritis patients with cardiovascular disease, the answer may be yes

A photo of a man鈥檚 hand with IV line attached and the vial and packaging of Aduhelm

Medicare Finalizes Limits on Aducanumab Coverage

But decision allows flexibility for some anti-amyloid Alzheimer's drugs

AAN over a photo of the Washington State Convention Center, Seattle, WA.

Memory Enhancer Succeeds in Phase II Alzheimer's Trial

Novel NMDA-targeted drug would expand options for symptomatic treatment

A photo of the vial and packaging of Aduhelm.

Aducanumab Data Finally Published, but Alzheimer's Experts Spot Problems

Questions raised about secondary endpoints

Illustration of a brain shaped maze.

Pimavanserin Resubmitted to FDA; APA's New President Elect; Bipolar Market Slowing

News and commentary from the psychiatry world

A cross section slice of a brain with Alzheimer鈥檚 disease

COVID Brain Changes Show Parallels With Alzheimer's Disease

Findings may point to potential mechanism for brain fog in people with long COVID

The packaging and vial of Aduhelm over a close up of a Medicare card

Medicare Plans to Restrict Coverage of New Alzheimer's Drug

Proposal would cover aducanumab (Aduhelm) in patients on qualifying clinical trials

An illustration depicting Alzheimer鈥檚 disease with amyloid plaques forming between neurons

Alzheimer's Drugs Race to FDA

After aducanumab, drug companies pivot to use the accelerated approval pathway

A photo of Viagra pills blister pack and packaging.

Can Viagra Prevent Alzheimer's?

Sildenafil shows potential for drug repurposing

The vial and packaging of Aduhelm (aducanumab) over a close up of a man鈥檚 hand with IV attached.

Let Ethics Guide Aducanumab Prescribing, AAN Says

Don't rely on FDA approval alone to make best choices for Alzheimer's patients

An MRI image of a brain with Alzheimer鈥檚 disease.

One Aducanumab Patient, Six Brain Edema Episodes

"Uniquely complicated course" for patient treated with new Alzheimer's drug

I'm a Neurologist With Alzheimer's

How knowledge helps the uncertainty

EASD over an illustration of a person's hand and blood glucose monitor and other icons associated with diabetes.

Healthy Lifestyle Keeps Dementia at Bay in Patients With Diabetes

Maintaining control of risk factors neutralized excess dementia risk

The packaging and blister packs of Ritalin (methylphenidate)

Stimulant Reduces Apathy in Alzheimer's Disease

Twice daily methylphenidate showed modest effect size

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