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Alzheimer's Disease

News, opinions and meeting coverage in psychiatry.

Tight BP Control Lowers Risk for Mild Cognitive Impairment

Data came from controversial SPRINT trial

Anti-Amyloid Drug Slows Cognitive Decline in Mid-Stage Trial

But will findings be replicated in phase III studies?

Tailored Lighting Improves Alzheimer's Patients Sleep, Mood

Exposure to specific light helped regulate circadian rhythms

Nabilone Effective for Easing Agitation in Alzheimer's

Cognition, neuropsychiatric symptoms also improved with synthetic cannabinoid

Alzheimer's Guidelines for Primary Care Announced

Take concerns seriously, communicate results clearly, guidelines recommend

Alzheimer's: Rethinking the 'One-Size-Fits-All' Approach

NIH conference emphasizes tailored prevention and treatment

Eyes Might ID Preclinical Alzheimer's

Presymptomatic patients show foveal thinning, retinal changes

AAN 2018: Rare Disease Breakthroughs and Novel Approaches

Noteworthy presentations at American Academy of Neurology meeting

NeuroBreak: Hits, Not Concussions, Cause CTE; Smoking and PD; APOE4 News

News and commentary from the world of neurology and neuroscience

NeuroBreak: U.S. Autism Prevalence Plateauing; Omalu Quits as Medical Examiner

News and commentary from the world of neurology and neuroscience

Speech Changes May Signal Cognitive Impairment

Prospective study suggests 'connected speech' assessment could be screening tool

Lifetime Stress May Boost Dementia Risk for Blacks

African Americans seem to experience cognitive issues earlier

Anti-Tau Drugs for PSP Move into Phase II

But phase I study of one agent pulled from presentation

AAN Debate: Neurologists Divided on Amyloid as Alzheimer Target

Many attendees say the pathway is still worth exploring

Daytime Sleepiness, Brain Pathology: A 2-Way Street?

Amyloid buildup may be both effect and cause of sleep-wake abnormalities in elderly

AAD: A Skin-Based Test for Alzheimer's Disease?

Small study show high Tau protein levels in buccal swabs

Watch Out for Brain Game Claims

Study wasn't powered to detect dementia outcomes

Risky Behaviors Common in Seniors With Probable Dementia

30% use cooking equipment, manage their own money

Donepezil Add-On Promising in Completer Analysis

Serotonin modulator slows but doesn't stop cognitive decline in phase II re-analysis.

Agent Orange Plus PTSD Equals Extra Dementia Risk

For Vietnam vets, defoliant exposure "may exacerbate effects of other risk factors."

T1D Patients Face Nearly Double Risk for Dementia

Findings still significant after controlling for vascular risk factors.

Copyright Issues Hinder MMSE Use

Neurologists forced to look for alternate cognitive screening tests

Gout May Protect Against Alzheimer's Disease

Study showed AD incidence higher over 5 years for patients without gout.

Dementia Tied to More ICD Placements

Dementia patients get more implantable cardioverter-defibrillators than expected, and even cognitively normal individuals may not understand their options about cardiac device replacement.

Anti-Amyloid Drug Has Mixed Results

COPENHAGEN -- The amyloid plaque-busting drug crenezumab for Alzheimer's disease slowed cognitive decline in patients with mild baseline impairment but missed its primary endpoint in a phase II trial.

HTN May Halt Dementia in Very Elderly

COPENHAGEN -- Among individuals who developed hypertension at age 90 or later, their risk of also developing dementia was dramatically lower than other very elderly people whose blood pressure remained normal.

APA Meeting Highlights Mental Health Biology

NEW YORK CITY -- The biological basis for normal and abnormal mental function is emerging as a dominant theme in psychiatry research, and the American Psychiatric Association annual meeting that starts here Saturday won't be an exception.

MoCA Beats MMSE to Assess Dementia

NEW ORLEANS -- The Montreal Cognitive Assessment (MoCA) was better than the Mini-Mental State Examination (MMSE) at teasing out subtle differences in cognitive performance among mildly impaired individuals, researchers reported here.

APA Leaders Defend New Diagnostic Guide

SAN FRANCISCO -- The fifth edition of the "psychiatrist's bible" was officially released here in all its 947-page glory, with its developers offering a spirited rebuttal to their critics.

DSM-5: What's In, What's Out

PHILADELPHIA -- Reports here provided what may be the last public update on DSM-5, the next edition of American psychiatry's diagnostic guide, before it is formally released in May 2013.

FDA Blocks Sale of Supplements for Parkinson's and Alzheimer's

WASHINGTON -- The FDA filed a permanent injunction against two Minnesota companies that distributed amino acid products marketed as treatments for Parkinson's disease, Alzheimer's disease, and a number of other neurological disorders.

The Top 10 Medical Advances of the Decade

From genome to hormones, doctors pick the top medical advances of the decade.

Recall of Three Little Words Helps Quick Diagnosis of Mild Cognitive Impairment

ATLANTA -- Mild cognitive impairment can be determined in less than five minutes with a three-word memory test and a clock- drawing task, according to researchers here. The words are apple, penny, and table.

Accelerated Weight Loss May Signal Imminent Dementia Onset

ST. LOUIS -- An early warning sign for Alzheimer's disease could be accelerated weight loss, found a study of aging and memory.

Blood Clots Linked to Alzheimer's and Vascular Dementias

MANCHESTER, England 芒鈧€� Spontaneous cerebral blood clots were detected at similar rates in patients with Alzheimer's disease and vascular dementia, suggesting a common pathology and a potentially preventable or treatable cause for some dementias, researchers here said.

FDA Warns of Excess Mortality to Elderly With Antipsychotics

WASHINGTON-The FDA has issued a public health advisory on the entire class of atypical antipsychotic drugs, pointing to an apparent excess of mortality for older patients with dementia, particularly when the agents are used off-label to treat behavioral disorders.