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Endocrinology

News, opinions and meeting coverage in endocrinology.

Antidepressants Have No Effect on Bone Loss

The use of selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants among women in midlife didn't lead to a greater rate of bone loss, a prospective cohort study found.

Xenical Helps PCOS Patients Slim Down

Lifestyle changes plus the weight-loss drug orlistat (Xenical) helped women with polycystic ovarian syndrome (PCOS) shed pounds, leading to metabolic improvements, researchers found.

Medicare's DME Bidding Program Criticized

Despite complaints from multiple parties, Medicare's bidding program for durable medical equipment -- including diabetes supplies -- now includes suppliers to half of all program beneficiaries.

Vitamin D, IGF-1, Growth Hormone Have Deep Ties

Vitamin D and insulin-like growth factor-1 (IGF-1) are involved in a complex interplay that may have implications for growth hormone dosing, researchers found.

Range of Due Dates Better for Expectant Moms

Pregnant women may be better off with a range of delivery dates rather than a set date due to variability in gestation times, researchers found.

Growth Hormone May Boost Heart Function, Too

Giving growth hormone to deficient patients with chronic heart failure may slow progression of the condition, researchers found.

FDA Goes After Fake Diabetes Therapies

The FDA has sent letters to 15 companies warning them to stop marketing products that falsely claim to treat diabetes, the agency announced.

A Little Estrogen Goes a Long Way in Preventing UTI

Short-term estrogen therapy induced cellular changes in urothelium consistent with improved ability to fight off urinary tract infection, results from clinical and preclinical studies suggested.

Society Seconds Call for Incretin Data

SAN FRANCISCO -- The Endocrine Society has joined its voice to the recent call for incretin drugmakers to release all patient-level data on their products, the group announced at its annual meeting.

AMA House Votes Against Council, Calls Obesity a Disease

CHICAGO -- Obesity should be called a disease and not simply a condition, the American Medical Association's policy-making House of Delegates voted on Tuesday, ignoring a recommendation by one of its own councils.

Obesity Not a Disease, AMA Council Says

CHICAGO -- Obesity is hard to define and diagnose, and partly because of that is not a disease, an American Medical Association council said in a report issued here Monday.

Diabetes Experts Divided About 'Lone Wolf' Butler

Top experts in diabetes and endocrinology have offered mixed reactions to a profile of Peter Butler, MD, chair of endocrinology at the University of California Los Angeles, in the New York Times.

Shots Best Way to Give B12 After Bariatric Surgery

Vitamin B12 injections are the preferred treatment for patients who develop a deficiency following bariatric surgery, researchers found.

Hypothyroidism Hikes Death Risk in Blacks

African Americans with hypothyroidism face an increased risk of death, and in patients with congestive heart failure, even mild underactive thyroid disease raises mortality risk, a retrospective cohort study found.

Low Potassium Linked with Liver Disease

Patients with non-alcoholic fatty liver disease also had low potassium levels, researchers in China found.

High-Salt Diet May Boost Cortisol

Eating a diet high in sodium increased levels of cortisol and other metabolites, potentially giving rise to metabolic syndrome, researchers found.

Withdrawal Not a Problem with Phentermine

Patients taking phentermine long-term to treat obesity don't have to worry about withdrawal when they come off it, researchers found.

Protein Rich Diet May Boost IVF Success

Results from a small study suggest that women whose diets consist of at least 25% protein may have more successful outcomes when undergoing assisted reproduction.

Finger Stick Has Promise as Prediabetes Test

PHOENIX -- Measuring capillary blood via finger stick assay was as accurate as venous blood sample assays in predicting 5-year likelihood of diabetes, researchers reported here.

Case Study Links 'Pot' to Pituitary Damage

PHOENIX -- Daily use of marijuana over 15 years was associated with a case of low testosterone, follicle-stimulating hormone, and luteinizing hormone, researchers reported here.

How Much Exercise to Burn Off a Burger?

Menus displaying the amount of exercise required to burn off calories in a meal had some impact on food choice, researchers found.

Full Thyroid Removal May be Best in Graves' Disease

Removing the whole thyroid lessens the chance of hyperthyroidism recurrence in Graves' disease compared with partial thyroidectomy, but it also leads to increased temporary hypoparathyroidism, researchers found.

FDA Splits on Safety of Endo's Aveed for Low-T

SILVER SPRING, Md. -- An FDA advisory committee was split Thursday on the safety of an injectable form of testosterone replacement, but voted overwhelmingly against a proposed risk mitigation plan.

C. Diff Dangerous in ESRD

ORLANDO -- Kidney dialysis patients who are infected with Clostridium difficile have a greater risk of infection relapse and also have a higher all-cause mortality that patients who do not have kidney disease, researchers said here.

Cardio Notes: Sex Improves with Stenting

Opening the arteries of those with stable coronary disease also opens the door to an improved sex life. Also this week, bariatric surgery helps remodel the heart.

Study Counters WHI on Risk of Hormones in Menopause

Hormone therapy may actually help the heart in some respects for newly menopausal women, a randomized trial showed, although the impact on hard outcomes like stroke and breast cancer still remains to be seen.

Weight Gain After Bypass Not Affected by Diet

SAN ANTONIO -- Lifestyle factors -- including dietary intake, physical activity levels, and treadmill time -- were not predictive of weight regain from 2 to 6 years after Roux-en-Y gastric bypass, researchers found.

Genetic Obesity Risk Heightened by Sugary Drinks

SAN ANTONIO -- The relationship between genetics, body mass index, and obesity risk appears to be magnified in adults who drink the most sugar-sweetened beverages, researchers found.

Low Preop Sodium Raises Mortality Risk

Preoperative hyponatremia significantly increased the risk of 30-day postsurgical mortality, a risk that extended across all subgroups of surgical patients, investigators reported.

Playing Sports Helps Teens Fight Fat

Team sports may fight weight problems better than other forms of exercise among high schoolers, researchers found.

NAMS Founder: WHI Wrong on HRT

A leader of the North American Menopause Society wants an independent review of all major publications from the Women's Health Initiative.

No Weight Gain with Linagliptin in Diabetes

The DPP-4 inhibitor linagliptin may control type 2 diabetes with less hypoglycemia or weight gain than glimepiride when used as second-line treatment with metformin, a trial showed.

Vitamin D Test Accuracy Called into Question

HOUSTON -- Two widely used tests to determine vitamin D status produced results that exceeded the allowable limits for error in at least 40% of cases, according to a study reported here.

Big Breakfast, Plus Dessert Aids Weight Loss

HOUSTON -- Obese adults lost significantly more weight by starting the day with a calorie-and carbohydrate-heavy breakfast that included a sweet treat, instead of saving more calories for dinner, according to a study reported here.

Testosterone Tx Helps Obese Men Trim Waistline

HOUSTON -- Obese hypogonadal men lost an average of 36 pounds during long-term testosterone replacement therapy, results of a prospective cohort study showed.

Lymphedema Tied to Obesity

Obesity may contribute to the development of lymphedema, a small study showed.

Tattoos Replace Bracelets for Medical Alerts

PHILADELPHIA -- As more people with diabetes replace their medical alert bracelets with tattooed warnings, there might be a need for a standard design and body location, a researcher here said.

Prolia Linked to Serious Skin Side Effects

RALEIGH, N.C. -- More than 40 serious cutaneous adverse events linked to the osteoporosis formulation of denosumab (Prolia) were discovered in a review of FDA records, investigators reported here.

DSM-5: What's In, What's Out

PHILADELPHIA -- Reports here provided what may be the last public update on DSM-5, the next edition of American psychiatry's diagnostic guide, before it is formally released in May 2013.

OTC Bug Bite Remedies of Little Help

Treating simple bug bites isn't usually necessary and there's little evidence to support doing so, a review warned.

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